Christian Haass
German Center for Neurodegenerative Diseases
497 Papers
4.8K Citations
Christian Haass is an academic researcher from German Center for Neurodegenerative Diseases. The author has contributed to research in topics: Presenilin & Biology. The author has an hindex of 119, co-authored 445 publications. Previous affiliations of Christian Haass include University of Tokyo & Center for Integrated Protein Science Munich.
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Papers
The emerging utility of animal models of chronic neurodegenerative diseases.
Philipp J. Kahle,Christian Haass +1 more
TL;DR: One hallmark lesion of AD, the neurofibrillary tangle, has been modelled recently in transgenic mice expressing mutant tau protein linked to frontotemporal dementia, and PD is characterised by intraneuronal cytoplasmic deposits of the PD-associated gene product α-synuclein.
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Proteolytic processing of Alzheimer’s disease associated proteins
Christian Haass,Jürgen Grünberg,Anja Capell,Christine Wild-Bode,Uwe Leimer,Jochen Walter,Tsuneo Yamazaki,I. Ihara,I. Zweckbronner,C. Jakubek,Ralf Baumeister +10 more
TL;DR: It is demonstrated that PS proteins are involved in NOTCH signaling FAD causing mutations interfere with the biological function of PS proteins in NotCH signaling.
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Patent
Dipeptide-repeat proteins as therapeutic target in neurodegenerative diseases with hexanucleotide repeat expansion
Dieter Edbauer,Christian Haass,Shih-Ming Weng,Kohji Mori,Arztberger Thomas,Elisabeth Kremmer +5 more
- 22 Jan 2014
TL;DR: In this article, a method of detecting a disease characterized by an expansion of genomic hexanucleotide repeats as well as polypeptides of said hexan nucleotide repeats, ligands specifically binding to the polyprotein, methods of identifying an inhibitor preventing the expression and/or aggregation of said polyprotein are presented.
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Parkin and Its Substrates
Christian Haass,Philipp J. Kahle +1 more
TL;DR: The Perspective authors speculate that defective targeting of a- synuclein for degradation by parkin results in accumulation of toxic a-synuclein aggregates that selectively kill dopaminergic neurons.
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Signatures of glial activity can be detected in the CSF proteome
Timo Eninger,Stephan A. Müller,Mehtap Bacioglu,Manuel Schweighauser,Marius Lambert,Luis F. Maia,Jonas J. Neher,Sarah M Hornfeck,Ulrike Obermüller,Gernot Kleinberger,Christian Haass,Philipp J. Kahle,Matthias Staufenbiel,Lingyan Ping,Duc M. Duong,Allan I. Levey,Nicholas T. Seyfried,Stefan F. Lichtenthaler,Mathias Jucker,Stephan A. Kaeser +19 more
TL;DR: Proteome analysis in cerebrospinal fluid of mouse models of AD and PD pathology allowed us to identify a panel of glial CSF proteins that largely match the transcriptomic changes, supporting their relevance as biomarker candidates to stage glial activation in patients with neurodegenerative diseases.
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