Background The B.1.617.2 (delta) variant of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes coronavirus disease 2019 (Covid-19), has contributed to ...

https://www.nejm.org/doi/pdf/10.1056/NEJMoa2108891

Effectiveness of Covid-19 Vaccines against the B.1.617.2 (Delta) Variant.

The WHO Nomenclature Committee for Factors of the HLA System met following the 14th International HLA and Immunogenetics Workshop in Melbourne, Australia in December 2005 and Buzios, Brazil during the 15th International HLA and Immunogenetics Workshop in September 2008. This report documents the additions and revisions to the nomenclature of HLA specificities following the principles established in previous reports (1–18).

https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1399-0039.2010.01466.x

Nomenclature for factors of the HLA system, 2010.

A rapid increase in coronavirus disease 2019 (Covid-19) cases due to the omicron (B.1.1.529) variant of severe acute respiratory syndrome coronavirus 2 in highly vaccinated populations has aroused concerns about the effectiveness of current vaccines. 

/pdf/covid-19-vaccine-effectiveness-against-the-omicron-b-1-1-529-1t8j1ngj.pdf

Covid-19 Vaccine Effectiveness against the Omicron (B.1.1.529) Variant

Exosomes are nanosized membrane vesicles released by fusion of an organelle of the endocytic pathway, the multivesicular body, with the plasma membrane. This process was discovered more than 30 years ago, and during these years, exosomes have gone from being considered as cellular waste disposal to mediate a novel mechanism of cell-to-cell communication. The exponential interest in exosomes experienced during recent years is due to their important roles in health and disease and to their potential clinical application in therapy and diagnosis. However, important aspects of the biology of exosomes remain unknown. To explore the use of exosomes in the clinic, it is essential that the basic molecular mechanisms behind the transport and function of these vesicles are better understood. We have here summarized what is presently known about how exosomes are formed and released by cells. Moreover, other cellular processes related to exosome biogenesis and release, such as autophagy and lysosomal exocytosis are presented. Finally, methodological aspects related to exosome release studies are discussed.

/pdf/current-knowledge-on-exosome-biogenesis-and-release-2tupxg3eeu.pdf

Current knowledge on exosome biogenesis and release

Current strategies of regenerative medicine are focused on the restoration of pathologically altered tissue architectures by transplantation of cells in combination with supportive scaffolds and biomolecules. In recent years, considerable interest has been given to biologically active scaffolds which are based on similar analogs of the extracellular matrix that have induced synthesis of tissues and organs. To restore function or regenerate tissue, a scaffold is necessary that will act as a temporary matrix for cell proliferation and extracellular matrix deposition, with subsequent ingrowth until the tissues are totally restored or regenerated. Scaffolds have been used for tissue engineering such as bone, cartilage, ligament, skin, vascular tissues, neural tissues, and skeletal muscle and as vehicle for the controlled delivery of drugs, proteins, and DNA. Various technologies come together to construct porous scaffolds to regenerate the tissues/organs and also for controlled and targeted release of bioactive agents in tissue engineering applications. In this paper, an overview of the different types of scaffolds with their material properties is discussed. The fabrication technologies for tissue engineering scaffolds, including the basic and conventional techniques to the more recent ones, are tabulated.

/pdf/polymeric-scaffolds-in-tissue-engineering-application-a-2sbenjc1po.pdf

Polymeric scaffolds in tissue engineering application: a review

Establishing a cell therapy unit in a blood bank is a new idea, which seemingly alleviates the current pressure to develop new therapies. However, the way Ahead is full of hurdles. Strategic planning is recommended and should be emphasized even more, as risks are high and cell therapies are costly. Especially, the mixture of staffing, designing facilities and organizational aspects are a burden. Executing the establishment in a step-by-step approach makes the tasks easier and has a high possibility of success.

How to establish and run a cell therapy unit in a blood bank

BACKGROUND Hepatitis C virus (HCV) is responsible for the majority of post-transfusion hepatitis cases. We compared the correlation and reproducibility of different screening and confirmatory tests. MATERIAL AND METHODS 1,406 samples of voluntary blood donors were tested in parallel using 3 enzyme-linked immuno sorbent assays (ELISA) for HCV antibodies. Those samples that were positive in at least 1 of the 3 tests were additionally tested in a 3rd-generation ELISA as well as in 3 different confirmatory tests. RESULTS 13 samples (0.92%) were repeat reactive in at least 1 of the ELISAs with different results in the confirmatory tests. Only 3 samples (0.21%) with high sample/cutoff ratios in the ELISAs were positive in all 3 confirmatory tests. CONCLUSIONS The reproducibility of the tested ELISAs and the correlation with confirmatory tests were good only in samples with a high signal to cutoff ratio. Two different high-positive ELISA results can be regarded as confirmation.

[Possibilities and limits of anti-HCV antibody screening in the blood donation service].

2Magnetic resonance imaging confirms the diagnosis of CPM. The disease has a poor prognosis and no effective treatment is established. The lesions are characterised by a loss of oligodendrocytes and myelin with preserved neuronal cell bodies and axons. 3 The histological similarity of CPM lesions with lesions from other demyelinating disorders, like multiple sclerosis, may lead to the assumption that these lesions have the same pathogenetic pathway. 4 However, the background remains unclear. In three cases with CPM we did extensive therapeutic plasmapheresis immediately after confirmation by magnetic resonance imaging (figure). A 29-year-old female patient with chronic alcohol abuse was admitted to hospital with nausea and diarrhoea. Hyponatraemia (107 mmol/L) was rapidly corrected with isotonic saline. 3 days later she had pseudoflabby tetraparesis, absent deep-tendon reflexes in the extremities, and abnormal bulbar movements. Plasmapheresis started with daily sessions over 4 days changing to twice a week for a further 3 weeks. In total 24 700 mL plasma was exchanged with albumin and cristalloid solutions. Tetraplegia resolved within 2 months. Silent signs of ataxia remained after 1 year. In a second case a 20-year-old female patient with anorexia nervosa (21 kg) was admitted to the hospital with diarrhoea and a sporadic seizure. Hyponatraemia (106 mmol/L) was slowly adjusted over 5 days to normal values. She then became somnolent and a complete spastic tetraparesis occurred together with dysarthria, dysphagia, and bulbar movement disorders. 5243 mL plasma was withdrawn in five plasmapheresis sessions. Equal amounts of albumin and cristalloid solutions were infused. One month later she was able to walk with assistance. The mental status test showed an impaired intermediate-term memory. In the third case a 30-year-old female patient with pneumonia and a history of chronic alcoholic abuse was referred to our hospital. After 2 weeks of treatment with cephalasporine mild hyponatraemia was corrected slowly

Treatment of central pontine myelinolysis with therapeutic

15-OR: A Multi-Site Study Employing High Resolution HLA Genotyping by Next Generation 454 GS FLX Sequencing

Summary We investigated the haemodynamic and respiratory effects of one-lung ventilation and carbon dioxide insufflation in 13 adult patients undergoing video-assisted thoracoscopy. Cardiorespiratory variables were determined during carbon dioxide insufflation at intrahemithoracic pressures of 5, 10 and 15 mmHg, and after 5 and 15 min of one-lung ventilation. Carbon dioxide insufflation was associated with a clear deterioration in circulatory function. The cardiac index decreased subsequent to increasing intrathoracic pressures. The mean cardiac index (SD) at pressures of 10 and 15 mmHg was 1.86 (0.39) and 1.52 (0.46), respectively, and may be compared with the reduced venous return consistent with tension pneumothorax. One-lung ventilation did not affect haemodynamic variables but reduced arterial oxygenation indices (PaO2/FIO2) from 424.29 (160.79) after induction of anaesthesia, to 207.72 (125.50) after 5 min and 172.04 (72.03) after 15 min of one-lung ventilation, respectively. The oxygenation index was not influenced by intrahemithoracic carbon dioxide insufflation. One-lung ventilation via a double-lumen endobronchial tube is safe and convenient for video-assisted thoracoscopic surgery. It has no further consequences on haemodynamic variables, whereas the compression of the lung by carbon dioxide insufflation may cause circulatory dysfunction.

The effects of one-lung ventilation compared with carbon dioxide insufflation

Handle everyday research tasks with reliable, citation-backed results

Your personal Research Agent to handle research tasks with citation-backed results

Popular Tasks used by Researchers

How can I help with your research?

Meet SciSpace

Get more enhanced response by uploading the PDFs you want me to reference.

No relevant PDFs in your library

SciSpace is the AI research assistant for academics. Run systematic literature reviews on 280M+ papers, and write papers with cited sources. Trusted by 1M+ students, PhDs & researchers.

SciSpace | AI for Research

Analyze PDFs

Code & Manuscripts

Funding & Grants

Literature & Patents

Medical & Clinical Data

Systematic Review

Visualize & Present

Web & Data

Build a Google Scholar-like website for your research.

Build a website

Create charts and images for your research

Create a Chart

Write a paper for submission to a journal

Draft a manuscript

Patent Search

Design eye-catching scientific posters in minutes.

Scientific Poster Generation

Systematic Literature Review

One task is running at the moment. Your messages will be shown right after.

Drag and drop or click here to browse

Loved by <highlight>1 million+</highlight> researchers

Extract a list of specific topics and their sources from unstructured text

Topics

Compare and analyze relevant papers that matches with your search

Papers

Get insights from PDFs and bookmarked papers from your library

My library

Recent searches

Try searching for:

Catch AI-generated content in scholarly and non-scholarly content

{ai} Detector

Ai Writer

Get PDF Summaries, highlighted text explanations 

Chat with PDF

Effortlessly create in-text citations and bibliographies in APA and 2,500 other formats

Citation generator

Get explanations, summaries, and answers on academic papers

Ease up your research workflow with {scispace}'s cohort of exciting AI tools

Elevate your academic writing skills and convey your ideas the way you want

Paraphraser

Explore our range of reading and writing tools

Your file is being prepared and should be ready in a few minutes. If it's a large file, it might take a bit longer. You can close this window, and we'll email you the file when it's done.

You have reached a maximum limit of <strong>{limit}</strong> columns in the table. Remove at least <strong>1</strong> column to add or create another one.

Christian Gabriel

Author Tools

Chat about Author