Christian G. Hartinger
University of Auckland
265 Papers
2.3K Citations
Christian G. Hartinger is an academic researcher from University of Auckland. The author has contributed to research in topics: Chemistry & Ruthenium. The author has an hindex of 67, co-authored 248 publications. Previous affiliations of Christian G. Hartinger include University of Vienna & École Polytechnique Fédérale de Lausanne.
Chat about Author
Papers
From Catalysis to Cancer: Toward Structure–Activity Relationships for Benzimidazol-2-ylidene-Derived N-Heterocyclic-Carbene Complexes as Anticancer Agents
Nelson Y. S. Lam,Dianna Truong,Hilke Burmeister,Maria V. Babak,Hannah U. Holtkamp,Sanam Movassaghi,Daniel M Ayine-Tora,Ayesha Zafar,Mario Kubanik,Luciano Oehninger,Tilo Söhnel,Jóhannes Reynisson,Stephen M. F. Jamieson,Christian Gaiddon,Ingo Ott,Christian G. Hartinger +15 more
TL;DR: A systematic study is presented in which symmetrically substituted methyl and benzyl derivatives with the nonsymmetric methyl/benzyl analogues are compared and the ability of the complexes to inhibit the selenoenzyme thioredoxin reductase (TrxR) and their cytotoxicity in human tumor cells is demonstrated.
67
Comparative solution equilibrium studies of anticancer gallium(III) complexes of 8-hydroxyquinoline and hydroxy(thio)pyrone ligands.
Éva A. Enyedy,Orsolya Dömötör,Erika Varga,Tamás Kiss,Tamás Kiss,Robert Trondl,Christian G. Hartinger,Christian G. Hartinger,Bernhard K. Keppler +8 more
TL;DR: In this article, the stochastic and stability constants of the Ga(III) complexes of 8-hydroxyquinoline (HQ), 8-hexoxyquinoline-5-sulfonate (HQS), maltol, thiomaltol, allomaltol and thioallmaltol were determined by means of pH-potentiometry, UV-vis spectrophotometry, spectrofluorometry and (1)H NMR spectroscopy in aqueous solution.
66
From hydrolytically labile to hydrolytically stable Ru(II)-arene anticancer complexes with carbohydrate-derived co-ligands.
Muhammad Hanif,Samuel M. Meier,Wolfgang Kandioller,Anna K. Bytzek,Michaela Hejl,Christian G. Hartinger,Alexey A. Nazarov,Alexey A. Nazarov,Vladimir B. Arion,Michael A. Jakupec,Paul J. Dyson,Bernhard K. Keppler +11 more
TL;DR: Structural alterations of a series of Ru(II)-arene complexes with carbohydrate-derived phosphite and biscarboxylato co-ligands led to a decrease in the tumor-inhibiting potency of the compounds in human cancer cell lines.
65
Quantitative bioimaging by LA-ICP-MS: a methodological study on the distribution of Pt and Ru in viscera originating from cisplatin- and KP1339-treated mice†
Alexander E. Egger,Sarah Theiner,Christoph Kornauth,Petra Heffeter,Petra Heffeter,Walter Berger,Walter Berger,Bernhard K. Keppler,Christian G. Hartinger,Christian G. Hartinger +9 more
TL;DR: Laser ablation-inductively coupled plasma-mass spectrometry (LA-ICP-MS) was used to study the spatially-resolved distribution of ruthenium and platinum in viscera originating from mice treated with the investigational r Ruthenium-based antitumor compound KP1339 or cisplatin.
64
Anticancer metallodrug research analytically painting the "omics" picture--current developments and future trends.
TL;DR: In this article, the authors review selected applications which led to a better understanding of the mode of action of clinically established metal-based anticancer agents and novel metallodrug candidates.
64