Christian Betzel
University of Hamburg
349 Papers
2.8K Citations
Christian Betzel is an academic researcher from University of Hamburg. The author has contributed to research in topics: Protein crystallization & Chemistry. The author has an hindex of 44, co-authored 330 publications. Previous affiliations of Christian Betzel include Eppendorf (Germany) & University of Tübingen.
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Papers
Crystallization and preliminary X-ray study of Vibrio cholerae uridine phosphorylase in complex with 6-methyluracil
I.I. Prokofev,A. A. Lashkov,Azat Gabdulkhakov,M. V. Dontsova,T. A. Seregina,Alexander Mironov,Christian Betzel,Al'bert M. Mikhailov +7 more
TL;DR: In this paper, the three-dimensional structure of the complex of 6-methyluracil (6-MU) with uridine phosphorylase has been investigated for the treatment of diseases of the gastrointestinal tract, including infectious diseases.
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Comparative crystallization and preliminary X-ray diffraction studies of locked nucleic acid and RNA stems of a tenascin C-binding aptamer.
Charlotte Förster,Arnd B. E. Brauer,Svenja Brode,Kathrin Schmidt,Markus Perbandt,Arne Meyer,Wojciech Rypniewski,Christian Betzel,Jens Kurreck,Jens P. Fürste,Volker A. Erdmann +10 more
TL;DR: Here, the crystallographic and X-ray diffraction data of the isolated aptamer stem encompassed in a six-base-pair duplex both with and without the LNA modification are presented.
Effect of macromolecular mass transport in microgravity protein crystallization
Arayik Martirosyan,Lawrence J. DeLucas,C. Schmidt,Markus Perbandt,Deborah McCombs,Martin Cox,Christopher D. Radka,Christian Betzel +7 more
TL;DR: In this paper, the effect of macromolecular transport and the incorporation of protein aggregate impurities in growing crystals was investigated on the International Space Station (ISS) and compared with control experiments performed in a 1G laboratory environment.
Massive X-ray screening reveals two allosteric drug binding sites of SARS-CoV-2 main protease
Sebastian Guenther,P. Reinke,Yaiza Fernández-García,J. Lieske,Thomas J. Lane,Helen M. Ginn,Faisal Hammad Mekky Koua,Christiane Ehrt,W. Ewert,Dominik Oberthuer,Oleksandr Yefanov,S. Meier,Kristina Lorenzen,Boris Krichel,Janine Kopicki,Luca Gelisio,W. Brehm,Ilona Dunkel,B. Seychell,Henry Gieseler,Brenna Norton-Baker,Beatriz Escudero-Pérez,M. Domaracky,S. Saouane,Aleksandra Tolstikova,Thomas P. White,Anna Haenle,M. Groessler,Holger Fleckenstein,F. Trost,M. Galchenkova,Y. Gevorkov,Chufeng Li,Salah Awel,Ariana Peck,Miriam Barthelmess,Frank Schluenzen,Xavier P Lourdu,N. Werner,H. Andaleeb,N. Ullah,Sven Falke,Vasundara Srinivasan,Bruno Alves Franca,M. Schwinzer,Hévila Brognaro,Cromarte Rogers,D. Melo,John J Doyle,Juraj Knoska,Gisel E. Peña Murillo,Aida Rahmani Mashhour,Filip Guicking,V. Hennicke,Pontus Fischer,J. Hakanpaeae,Jan Meyer,Philip Gribbon,Bernhard Ellinger,Maria Kuzikov,Markus Wolf,Andrea Rosario Beccari,Gleb Borenkov,David von Stetten,Guillaume Pompidor,Isabel Bento,Saravanan Panneerselvam,Ivars Karpics,Thomas R. Schneider,Maria Marta Garcia Alai,Stephan Niebling,Christian Guenther,C. Schmidt,Robin Schubert,Huijong Han,J. Boger,Diana C. F. Monteiro,Linlin Zhang,Xinyuanyuan Sun,J. Pletzer-Zelgert,J. Wollenhaupt,Christian G. Feiler,Manfred S. Weiss,Eike C. Schulz,Pedram Mehrabi,Katarina Karničar,Aleksandra Usenik,Jure Loboda,Henning Tidow,Ashwin Chari,Rolf Hilgenfeld,Charlotte Uetrecht,Russell J. Cox,Andrea Zaliani,Tobias Beck,Matthias Rarey,S. Guenther,Dušan Turk,Winfried Hinrichs,Henry N. Chapman,Arwen R. Pearson,Christian Betzel,Alke Meents +102 more
TL;DR: A massive X-ray crystallographic screen of repurposing drug libraries containing 5953 individual compounds against the SARS-CoV-2 main protease (Mpro), which is a potent drug target as it is essential for the virus replication.
Enzyme activity and structural features of three single-domain phloem cyclophilins from Brassica napus.
Patrizia Hanhart,Sven Falke,Marcel Y. Garbe,Victoria Rose,Melanie Thieß,Christian Betzel,Julia Kehr +6 more
TL;DR: The hypothesis that single domain phloem CYPs are activePhloem PPIases that may function as chaperones that has been postulated for divergent CYPs is supported.