Christian Betzel
University of Hamburg
349 Papers
2.8K Citations
Christian Betzel is an academic researcher from University of Hamburg. The author has contributed to research in topics: Protein crystallization & Chemistry. The author has an hindex of 44, co-authored 330 publications. Previous affiliations of Christian Betzel include Eppendorf (Germany) & University of Tübingen.
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Papers
Strategy to design peptide inhibitors: structure of a complex of proteinase K with a designed octapeptide inhibitor N-Ac-Pro-Ala-Pro-Phe-DAla-Ala-Ala-Ala-NH2 at 2.5 A resolution
TL;DR: The crystal structure of a complex formed by the interaction between proteinase K and a designed octapeptide amide and an extended electron density for a designed synthetic peptide inhibitor is determined, for the first time, in the prime region of an enzyme of the subtilisin family.
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Structural insights into serine protease inhibition by a marine invertebrate BPTI Kunitz-type inhibitor.
Rossana García-Fernández,Tirso Pons,Markus Perbandt,Pedro A. Valiente,Ariel Talavera,Yamile González-González,Dirk Rehders,María A. Chávez,Christian Betzel,Lars Redecke +9 more
TL;DR: The structure provides important information for site directed mutagenesis to further optimize the activity of rShPI-1A for biotechnological applications and remained largely conserved compared to mammalian BPTI-Kunitz inhibitor complexes.
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The X-ray structure of Salmonella typhimurium uridine nucleoside phosphorylase complexed with 2,2'-anhydrouridine, phosphate and potassium ions at 1.86 A resolution.
A. A. Lashkov,N. E. Zhukhlistova,Azat H. Gabdoulkhakov,Alexander A. Shtil,Roman G. Efremov,Christian Betzel,Al'bert M. Mikhailov +6 more
TL;DR: The X-ray crystal structure of Salmonella typhimurium uridine nucleoside phosphorylase complexed with its inhibitor 2,2'-anhydrouridine, phosphate and potassium ions has been solved and refined.
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Insights into metal ion binding in phospholipases A2: ultra high-resolution crystal structures of an acidic phospholipase A2 in the Ca2+ free and bound states.
Mário T. Murakami,A.G. Gabdoulkhakov,Nicolay Genov,Adélia Cristina Oliveira Cintra,Christian Betzel,Raghuvir K. Arni +5 more
TL;DR: Crystal structures of an acidic phospholipase A(2) from the venom of Bothrops jararacussu have been determined both in the Ca(2+) free and bound states at 0.97 and 1.60 A resolutions, respectively.
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Preliminary investigation of the three-dimensional structure of Salmonella typhimurium uridine phosphorylase in the crystalline state.
Maria V. Dontsova,A.G. Gabdoulkhakov,Olga K. Molchan,Alexandr A. Lashkov,Maria Garber,A. S. Mironov,Nadegda E. Zhukhlistova,Ekaterina Morgunova,Wolfgang Voelter,Christian Betzel,Yang Zhang,Steven E. Ealick,Al'bert M. Mikhailov +12 more
TL;DR: The hexameric StUPh model reveals a close structural relationship to Escherichia coli uridine phosphorylase (EcUPh), which catalyzes the phosphorolytic cleavage of the C-N glycosidic bond of uridine to ribose 1-phosphate and uracil in the pyrimidine-salvage pathway.