Chris Proschel
University of Rochester
11 Papers
25 Citations
Chris Proschel is an academic researcher from University of Rochester. The author has contributed to research in topics: Cellular differentiation & Oligodendrocyte. The author has an hindex of 6, co-authored 10 publications. Previous affiliations of Chris Proschel include University of Rochester Medical Center & Baylor College of Medicine.
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Papers
Embryonic-Derived Glial-Restricted Precursor Cells (GRP Cells) Can Differentiate into Astrocytes and Oligodendrocytes in Vivo
Juan J. Herrera,Hui Yang,Su-Chun Zhang,Chris Proschel,Patrick A. Tresco,Ian D. Duncan,Marla B. Luskin,Margot Mayer-Pröschel,Margot Mayer-Pröschel +8 more
TL;DR: It is suggested that the lineage restriction of GRP cells and their ability to generate both oligodendrocytes and astrocyte in vivo together with their embryonic character that allows for extensive in vitro expansion of the population makes the cell useful for clinical application.
100
Redox regulation of precursor cell function: insights and paradoxes.
TL;DR: Findings indicate that intracellular redox state is utilized by the organism as a means of regulating the balance between progenitor cell division and differentiation, and Paradoxically, the results obtained through studies on the oligodendrocyte lineage are precisely the opposite of what might be predicted.
89
Oxidative-reductionist approaches to stem and progenitor cell function.
TL;DR: It is demonstrated that oxidation promotes self-renewal of neuroepithelial stem cells, revealing fascinating differences-and surprising similarities-with how redox pathways regulate glial progenitor cells.
19
Patent
Transplantation of Glial Restricted Precursor-Derived Astrocytes for Promotion of Axon Growth
Chris Proschel,Margot Mayer-Pröschel,Jeannette E. Davies,Stephen J.A. Davies,Mark Noble +4 more
- 28 Aug 2006
TL;DR: In this paper, compositions and methods for the treatment of central nervous system (CNS) lesions comprising administration of glial restricted precursor (GRP) derived astrocytes (GDAs).
6
Patent
The redox/fyn/c-cbl pathway
Mark Noble,Chris Proschel,Zaibo Li,Brett M. Stevens,Yin Miranda Yang,Tiefei Dong +5 more
- 16 Jan 2008
TL;DR: Methods and compositions related to a novel cellular pathway, the redox/Fyn/c-Cbl pathway, include a variety of aspects, including agents that selectively interrupt the pathway and methods of using the same.