Chris J. Paddon
Amyris
12 Papers
10 Citations
Chris J. Paddon is an academic researcher from Amyris. The author has contributed to research in topics: Artemisia annua & Medicine. The author has an hindex of 9, co-authored 9 publications.
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Papers
Production of amorphadiene in yeast, and its conversion to dihydroartemisinic acid, precursor to the antimalarial agent artemisinin
Patrick J. Westfall,Douglas J. Pitera,Jacob R. Lenihan,Diana Eng,Frank X. Woolard,Rika Regentin,Tizita Horning,Hiroko Tsuruta,David J. Melis,Andrew Owens,Scott Fickes,Don Diola,Kirsten R. Benjamin,Jay D. Keasling,Michael D. Leavell,Derek McPhee,Neil Stephen Renninger,Jack D. Newman,Chris J. Paddon +18 more
TL;DR: Progress is described toward the goal of developing a supply of semisynthetic artemisinin based on production of the art Artemisinin precursor amorpha-4,11-diene by fermentation from engineered Saccharomyces cerevisiae, and its chemical conversion to dihydroartemisinic acid, which can be subsequently converted to artemis inin.
707
Semi-synthetic artemisinin: a model for the use of synthetic biology in pharmaceutical development
Chris J. Paddon,Jay D. Keasling +1 more
TL;DR: This Review describes the metabolic engineering and synthetic biology approaches that were used to develop this important antimalarial drug precursor and illuminates how lessons learned from this work could be applied to the production of other pharmaceutical agents.
663
Balancing a heterologous mevalonate pathway for improved isoprenoid production in Escherichia coli.
TL;DR: The results demonstrate that balancing carbon flux through the heterologous pathway is a key determinant in optimizing isoprenoid biosynthesis in microbial hosts and eliminated the pathway bottleneck and increased mevalonate production.
515
Developing fermentative terpenoid production for commercial usage.
TL;DR: Some terpenoids that are currently in commercial production or development are reviewed, ranging from semisynthetic production of the antimalarial drug artemisinin, through fragrance molecules, to commodity chemicals such as isoprene and β-farnesene.
108
Developing Commercial Production of Semi-Synthetic Artemisinin, and of β-Farnesene, an Isoprenoid Produced by Fermentation of Brazilian Sugar
TL;DR: Production of β-farnesene from Brazilian sugarcane offers several environmental advantages and its use as a feedstock for making biodegradable lubricants is highlighted, highlighting a powerful new suite of technologies that will become increasingly important for production of chemicals.