Chris Galanos
Max Planck Society
176 Papers
4.3K Citations
Chris Galanos is an academic researcher from Max Planck Society. The author has contributed to research in topics: Lipid A & Lipopolysaccharide. The author has an hindex of 63, co-authored 175 publications. Previous affiliations of Chris Galanos include University of Texas Southwestern Medical Center.
Chat about Author
Papers
Enhancement of endotoxin lethality and generation of anaphylactoid reactions by lipopolysaccharides in muramyl-dipeptide-treated mice.
H Takada,Chris Galanos +1 more
TL;DR: The present findings strongly suggest that the early- and late-phase reactions induced by MDP and LPS are caused by different mechanisms.
75
A point mutation in the IL-12R beta 2 gene underlies the IL-12 unresponsiveness of Lps-defective C57BL/10ScCr mice.
Alexander Poltorak,Thomas Merlin,Peter J. Nielsen,O. Sandra,Irina Smirnova,Ingo Schupp,Thomas Boehm,Chris Galanos,Marina A. Freudenberg +8 more
TL;DR: It is shown here that this second defect of Cr mice is due to a mutation in a single gene located on mouse chromosome 6, in close proximity to the Igκ locus, which is IL-12Rβ2, responsible for their defective IFN-γ response to microorganisms.
74
Role of lipopolysaccharide susceptibility in the innate immune response to Salmonella typhimurium infection: LPS, a primary target for recognition of Gram-negative bacteria
Marina A. Freudenberg,Thomas Merlin,Marina Gumenscheimer,Christoph Kalis,Regine Landmann,Chris Galanos +5 more
TL;DR: This review deals with the factors affecting LPS susceptibility and with the role of the latter in the course and outcome of Salmonella typhimurium infection.
74
Gamma interferon production in endotoxin-responder and -nonresponder mice during infection.
TL;DR: In addition to the defect in LPS responsiveness, C57BL/10ScCr mice possess a defect in IFN-gamma production in response to different stimuli; this production could be enhanced further by ConA.
72
Biological activity of synthetic heptaacyl lipid A representing a component of Salmonella minnesota R595 lipid A
Chris Galanos,Otto Lüderitz,Marina A. Freudenberg,Lore Brade,Ulrich Schade,Ernst Th. Rietschel,Shoichi Kusumoto,Tetsuo Shiba +7 more
TL;DR: It was found that the synthetic preparation was, in typical in vivo endotoxin tests (lethality, pyrogenicity, Shwartzman reactivity) as well as in its antigenicity and macrophage activation capacity, significantly less active than natural Salmonella lipid A.
70