Chris Galanos
Max Planck Society
176 Papers
4.3K Citations
Chris Galanos is an academic researcher from Max Planck Society. The author has contributed to research in topics: Lipid A & Lipopolysaccharide. The author has an hindex of 63, co-authored 175 publications. Previous affiliations of Chris Galanos include University of Texas Southwestern Medical Center.
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Papers
Cutting Edge: A Murine, IL-12-Independent Pathway of IFN-γ Induction by Gram-Negative Bacteria Based on STAT4 Activation by Type I IFN and IL-18 Signaling
Marina A. Freudenberg,Thomas Merlin,Christoph Kalis,Yolande Chvatchko,Hella Stübig,Chris Galanos +5 more
TL;DR: It is shown that IFN-αβ alone induces tyrosine phosphorylation of STAT4 in murine splenocytes of different mouse strains, and in contradiction to current dogma, this pathway participates in the induction of IFn-γ by Gram-negative bacteria.
Toll‐like receptor 4 expression levels determine the degree of LPS‐susceptibility in mice
Christoph Kalis,Benoît Kanzler,Annalisa Lembo,Alexander Poltorak,Chris Galanos,Marina A. Freudenberg +5 more
TL;DR: In macrophages, investigation of the LPS‐induced cytokine (IL‐6) response revealed a linear relationship between the response and the logarithm ofTLR4–MD‐2 levels, indicating that TLR4 is the only limiting factor for LPS responsiveness in Cr mice.
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Are antimitochondrial antibodies in primary biliary cirrhosis induced by r(rough)-mutants of enterobacteriaceae?
R. Stemerowicz,Bernd Möller,Arne Rodloff,Marina A. Freudenberg,Uwe Hopf,Christel Wittenbrink,Richard Reinhardt,Richard Reinhardt,Chris Galanos +8 more
TL;DR: It seems that PBC-specific antigens are expressed in gram-negative bacteria and that these antigen may be immunogenic in mutants with defective polysaccharide synthesis, and the hypothesis of a bacterial aetiology for PBC is supported.
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Nontransformed, GM-CSF–dependent macrophage lines are a unique model to study tissue macrophage functions
György Fejer,Mareike Dorothee Wegner,Ildiko Györy,Idan Cohen,Peggy Engelhard,Elena Voronov,Thomas Manke,Zsolt Ruzsics,Lars Dölken,Olivia Prazeres da Costa,Nora Branzk,Michael Huber,Antje Prasse,Robert Schneider,Ron N. Apte,Chris Galanos,Marina A. Freudenberg +16 more
TL;DR: The generation of nontransformed murine macrophages is reported, which are similar to alveolar Macrophages and can be grown continuously without change of phenotype and in unlimited amounts, and offer an useful tool to study macrophage biology and for biomedical science.
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Biological activities of synthetic lipid A analogs: pyrogenicity, lethal toxicity, anticomplement activity, and induction of gelation of Limulus amoebocyte lysate.
K Tanamoto,Ulrich Zähringer,G R McKenzie,Chris Galanos,Ernst Th. Rietschel,O Lüderitz,Shoichi Kusumoto,Tetsuo Shiba +7 more
TL;DR: chemical synthesized lipid A analogs were investigated for several endotoxic activities, including pyrogenicity, lethal toxicity, anticomplement activity, and the capacity to gelate Limulus amoebocyte lysate in comparison to natural lipid A.
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