Chris Galanos
Max Planck Society
176 Papers
4.3K Citations
Chris Galanos is an academic researcher from Max Planck Society. The author has contributed to research in topics: Lipid A & Lipopolysaccharide. The author has an hindex of 63, co-authored 175 publications. Previous affiliations of Chris Galanos include University of Texas Southwestern Medical Center.
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Papers
Differential determination of the 3-Deoxy-D-mannooctulosonic acid residues in lipopolysaccharides of Salmonella minnesota rough mutants.
TL;DR: Different applications of the thiobarbituric acid assay were used to determine C4/5-unsubstituted, heptosyl-subst ituted and total 3-deoxy-d-mannooctulosonic acid (dOclA) in lipopolysaccharides of Salmonella minnesota rough mutants.
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Interaction of lipopolysaccharides with plasma high-density lipoprotein in rats.
TL;DR: Results may indicate that HDL represents a transport protein for LPS in plasma to organs of clearance or to other cellular targets.
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Relation between Escherichia coli R(rough)-forms in gut, lipid A in liver, and primary biliary cirrhosis.
Uwe Hopf,R. Stemerowicz,Arne Rodloff,Chris Galanos,Bernd Möller,Hartmut Lobeck,Marina A. Freudenberg,Dieter Huhn +7 more
TL;DR: The hypothesis that intestinal enterobacterial R-forms are aetiologically important in PBC and that antigens released from the bacterial cell wall contribute to the pathogenesis of the disease is supported.
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Chemical structure of E. Coli Lipid A: Linkage site of acyl groups in the disaccharide backbone
Masahiro Imoto,Shoichi Kusumoto,Tetsuo Shiba,Hideo Naoki,Takashi Iwashita,E.Th. Rietschel,Horst-Werner Wollenweber,Chris Galanos,Otto Lüderitz +8 more
TL;DR: The structure of the lipid A component of E. coli lippopolysaccharide was determined by means of chemical and 2D-NMR methods unequivocally to be a glucosamine β(1′-6)-disaccharide 1,4′-diphosphate acylated at the two hydroxyl (positions C-3 and −3′) and the two amino groups.
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•Journal Article
Antitumor Effect of the Human Immunodeficiency Virus Protease Inhibitor Ritonavir: Induction of Tumor-Cell Apoptosis Associated with Perturbation of Proteasomal Proteolysis
Simone Gaedicke,Elke Firat-Geier,Oana Constantiniu,Maria Lucchiari-Hartz,Marina A. Freudenberg,Chris Galanos,Gabriele Niedermann +6 more
TL;DR: It is found that ritonavir activates the chymotrypsin-like activity of isolated 26S proteasomes, in strong contrast to its effect on isolated 20S proteAsomes, and suggests that selective perturbation of proteasomal protein degradation may play a role in the antitumoral activities of ritonvir.
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