Chris Galanos
Max Planck Society
176 Papers
4.3K Citations
Chris Galanos is an academic researcher from Max Planck Society. The author has contributed to research in topics: Lipid A & Lipopolysaccharide. The author has an hindex of 63, co-authored 175 publications. Previous affiliations of Chris Galanos include University of Texas Southwestern Medical Center.
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Papers
Bloodstream infections: epidemiology, pathophysiology and therapeutic perspectives.
Reinaldo Salomão,Otelo Rigato,Antonio Carlos Campos Pignatari,Marina A. Freudenberg,Chris Galanos +4 more
TL;DR: The term sepsis syndrome should no longer be used as it is confusing and ambiguous and the need for more uniform concepts is of paramount importance for the design and evaluation of new therapeutic strategies.
Hepatocellular clearance function of bacterial lipopolysaccharides and free lipid A in mice with endotoxic shock
TL;DR: The data indicate that LPS and lipid A interact in vivo with Kupffer cells and hepatocytes, and Hepatic clearance of endotoxin seems to be independent of complement.
Enhanced B-cell activation mediated by TLR4 and BCR crosstalk
Susana Minguet,Elaine P. Dopfer,Careen Pollmer,Marina A. Freudenberg,Chris Galanos,Michael Reth,Michael Huber,Wolfgang W. A. Schamel +7 more
TL;DR: It is shown that primary B cells can efficiently discriminate between different LPS chemotypes, responding with at least 100‐fold higher sensitivity to rough‐ form LPS compared with smooth‐form LPS.
Immunogenic Properties of Lipid A
Chris Galanos,Marina A. Freudenberg,F. Jay,D. Nerkar,K. Veleva,H. Brade,Wolfgang Strittmatter +6 more
TL;DR: Antibodies to lipid A were induced in rabbits, but not in mice, following a single injection of immunogenic lipid A, and because of similarities between the lipid A of many gram-negative bacteria, antibodies to cholesterol showed wide cross-reactions.
Requirement for TLR9 in the Immunomodulatory Activity of Propionibacterium acnes
Christoph Kalis,Marina Gumenscheimer,Nikolaus Freudenberg,Sandrine Tchaptchet,György Fejer,Antje Heit,Shizuo Akira,Chris Galanos,Marina A. Freudenberg +8 more
TL;DR: It is shown in this study that TLR9 is crucial in generating the characteristic effects of killed P. acnes priming in the spleen, such as extramedullary hemopoiesis and organ enlargement, and granuloma formation in the liver.