Chris Galanos
Max Planck Society
176 Papers
4.3K Citations
Chris Galanos is an academic researcher from Max Planck Society. The author has contributed to research in topics: Lipid A & Lipopolysaccharide. The author has an hindex of 63, co-authored 175 publications. Previous affiliations of Chris Galanos include University of Texas Southwestern Medical Center.
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Papers
Modification of the silver staining technique to detect lipopolysaccharide in polyacrylamide gels.
TL;DR: By omitting this fixing step, which was originally developed for detecting proteins, and increasing the LPS oxidation time, the ability to detect LPS fractions that otherwise would not be stained is restored, providing a fast, simple, and sensitive way to analyze LPS in polyacrylamide gels despite the number of acyl groups present.
Absence of TRIF Signaling in Lipopolysaccharide-Stimulated Murine Mast Cells
Simone Keck,Ines Müller,György Fejer,Iva Savic,Sandrine Tchaptchet,Peter J. Nielsen,Chris Galanos,Michael Huber,Marina A. Freudenberg +8 more
TL;DR: It is shown how the response to the same microbial ligand using the same receptor can be regulated in different cell types of the innate immune system, including bone marrow-derived mast cells and BMMCs.
Endotoxic properties of chemically synthesized lipid A part structures. Comparison of synthetic lipid A precursor and synthetic analogues with biosynthetic lipid A precursor and free lipid A.
Chris Galanos,Volker Lehmann,Otto Lüderitz,Ernst Th. Rietschel,Otto Westphal,Helmut Brade,Lore Brade,Marina A. Freudenberg,Thomas Hansen-Hagge,Thomas Lüderitz,Gerry McKENZIE,Ulrich Schade,Wolfgang Strittmatter,Ken-Ichi Tanamoto,Ulrich Zähringer,Masahiro Imoto,Hiroyuki Yoshimura,Michiharu Yamamoto,Tetsuo Shimamoto,Shoichi Kusumoto,Tetsuo Shiba +20 more
TL;DR: The results show that the endotoxic principle of lipopolysaccharides, as postulated previously is embedded in the lipid A component and suggest initial conclusions on the structural requirements for the expression of endotoxin activities.
Effects of Granulocyte Colony-Stimulating Factor on Plasma Cytokine and Cytokine Receptor Levels and on the In Vivo Host Response to Endotoxin in Healthy Men
Thomas Pollmächer,Carsten Korth,Janet Mullington,Wolfgang Schreiber,Joachim Sauer,Helmut Vedder,Chris Galanos,Florian Holsboer +7 more
TL;DR: It is concluded that a single stand dose of G-CSF increases the plasma levels of cytokines and cytokine receptors and considerably modifies the host response of healthy humans to a low dose of endotoxin.
Lipopolysaccharide sensing an important factor in the innate immune response to Gram-negative bacterial infections: Benefits and hazards of LPS hypersensitivity
Marina A. Freudenberg,Sandrine Tchaptchet,Simone Keck,György Fejer,Michael Huber,Nicole Schütze,Bruce Beutler,Chris Galanos +7 more
TL;DR: This review summarizes investigations concerning the differential importance of CD14 and LBP in toll-like receptor 4/myeloid differentiation protein-2-mediated signaling by smooth and rough-form lipopolysaccharide (LPS) chemotypes and includes the results obtained in studies with murine and human TLR4-transgenic mice.