Chris Galanos
Max Planck Society
176 Papers
4.3K Citations
Chris Galanos is an academic researcher from Max Planck Society. The author has contributed to research in topics: Lipid A & Lipopolysaccharide. The author has an hindex of 63, co-authored 175 publications. Previous affiliations of Chris Galanos include University of Texas Southwestern Medical Center.
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Papers
Electrodialysis of lipopolysaccharides and their conversion to uniform salt forms.
Chris Galanos,Otto Lüderitz +1 more
TL;DR: The lipid A which is so far known as a water-insoluble material showed increased solubility when prepared from electrodialyzed lipopolysaccharides, which is related to differences in the sedimentation coefficients of the various salt forms.
Phase II trial of intravenous endotoxin in patients with colorectal and non-small cell lung cancer.
Florian Otto,Peter Schmid,A. Mackensen,U. Wehr,A. Seiz,M. Braun,Chris Galanos,R H Mertelsmann,R. Engelhardt +8 more
TL;DR: Tolerance of the macrophage system to the stimulatory effect of endotoxin, as measured by human necrosis factor alpha (TNF-alpha) release into serum, built up after the first administration and remained at a steady-state level after each subsequent injection.
R-form LPS, the master key to the activation of TLR4/MD-2-positive cells
Michael Huber,Christoph Kalis,Simone Keck,Zhengfan Jiang,Philippe Georgel,Xin Du,Louis Shamel,Sosathya Sovath,Suzanne Mudd,Bruce Beutler,Chris Galanos,Marina A. Freudenberg +11 more
TL;DR: The R‐form LPS constitutes ubiquitously part of the total LPS present in all wild‐type bacteria its contribution to the innate immune response and pathophysiology of infection is much higher than anticipated during the last half century.
Bacterial sensing, cell signaling, and modulation of the immune response during sepsis.
Reinaldo Salomão,Milena Karina Coló Brunialti,Marjorie Marini Rapozo,Giovana Lotici Baggio-Zappia,Chris Galanos,Marina A. Freudenberg +5 more
TL;DR: This review discusses aspects of bacterial recognition and induced cellular activation during sepsis, and focuses on LPS and host interactions as a clue to understand microorganisms sensing and cell signaling.