Chris Galanos
Max Planck Society
176 Papers
4.3K Citations
Chris Galanos is an academic researcher from Max Planck Society. The author has contributed to research in topics: Lipid A & Lipopolysaccharide. The author has an hindex of 63, co-authored 175 publications. Previous affiliations of Chris Galanos include University of Texas Southwestern Medical Center.
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Papers
Isolation and characterization of the tetrasaccharide (bis)phosphate from the glycosyl backbone of Salmonella minnesota and Escherichia coli re-mutant lipopolysaccharides
TL;DR: Intact tetrasaccharide mono- and bisphosphates were isolated from deep rough mutant strains of Salmonella minnesota and Escherichia coli and their chemical structure was unequivocally characterized by 1 H, 13 C, 31 P-NMR spectrometry and FAB-MS.
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Endotoxin Primes Perfused Rabbit Lungs for Enhanced Vasoconstrictor Response to Staphylococcal α-Toxin
Dieter Walmrath,Mathias Griebner,Burkhard Kolb,Friedrich Grimminger,Chris Galanos,Ulrich Schade,Werner Seeger +6 more
TL;DR: It is concluded that endotoxin primes rabbit lungs for enhanced prostanoid generation and pulmonary hypertension in response to S. aureus alpha-toxin, and cooperativity of endotoxin priming and exotoxin triggering may be relevant in critically ill patients suffering from both endotoxemia and gram-positive sepsis.
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Isolation of 4-amino-4-deoxy-L-arabinose from S and R form bacterial lipopolysaccharides.
TL;DR: During the course of mild acid hydrolysis of the lipopolysaccharides (LPS) isolated from several Salmonella species, a positively-charged sugar which migrated faster than glucosamine on paper electropherograms was observed, which has been identified as 4-amino-4-deoxyL-arabinose.
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The role of macrophages in the uptake of endotoxin by the mouse liver.
Nikolaus Freudenberg,Piotraschke J,Chris Galanos,C. Sorg,Askaryar Fa,Klosa B,H. U. Usener,Marina A. Freudenberg +7 more
TL;DR: The results show that in normal B10.D2 mice the liver macrophages constitute a heterogeneous population of cells which, depending on their state of differentiation, are distinguished by their differential distribution in the liver acinus and by their ability to phagocytose latex.
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Formation of interferon-gamma and tumor necrosis factor in mice during Salmonella typhimurium infection.
TL;DR: Formation of interferon-gamma (IFN-Gamma) and tumor necrosis factor (TNF) during Salmonella typhimurium infection was investigated in lipopolysaccharide (LPS)-sensitive C3H/HeN and C57BL/10ScSn(B10Sc Sn), and LPS-resistant (lpsd mutant) C3h/HeJ and B10ScCr(B 10ScCr) mice.
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