Chris Galanos
Max Planck Society
176 Papers
4.3K Citations
Chris Galanos is an academic researcher from Max Planck Society. The author has contributed to research in topics: Lipid A & Lipopolysaccharide. The author has an hindex of 63, co-authored 175 publications. Previous affiliations of Chris Galanos include University of Texas Southwestern Medical Center.
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Papers
Crucial role for human Toll-like receptor 4 in the development of contact allergy to nickel
Marc Schmidt,Badrinarayanan Raghavan,Badrinarayanan Raghavan,Verena Müller,Verena Müller,Thomas Vogl,György Fejer,Sandrine Tchaptchet,Simone Keck,Christoph Kalis,Peter J. Nielsen,Chris Galanos,Johannes Roth,Arne Skerra,Stefan F. Martin,Marina A. Freudenberg,Matthias Goebeler,Matthias Goebeler +17 more
TL;DR: It is shown that Ni2+ triggered an inflammatory response by directly activating human Toll-like receptor 4 (TLR4), which implicate site-specific human TLR4 inhibition as a potential strategy for therapeutic intervention in CHS that would not affect vital immune responses.
588
Lethal toxicity of lipopolysaccharide and tumor necrosis factor in normal and D-galactosamine-treated mice.
TL;DR: The hypothesis that TNF is a mediator of lethal toxicity of endotoxin is supported, showing that the early biochemical alterations in the liver known to be necessary for sensitization to LPS are also necessary for sensitivity to TNF.
Synthetic and natural Escherichia coli free lipid A express identical endotoxic activities
Chris Galanos,Otto Lüderitz,Ernst Th. Rietschel,Otto Westphal,Helmut Brade,Lore Brade,Marina A. Freudenberg,Ulrich Schade,Masahiro Imoto,Hiroyuki Yoshimura,Shoichi Kusumoto,Tetsuo Shiba +11 more
TL;DR: It was found that synthetic and natural free lipid A exhibit identical activities and are indistinguishable in all tests.
533
Lipopolysaccharides of Gram-Negative Bacteria
Otto Lüderitz,Marina A. Freudenberg,Chris Galanos,Volker Lehmann,Ernst Th. Rietschel,Derek H. Shaw +5 more
TL;DR: The studies indicate that at least some lipid A activities are not restricted to one specific structure, but are rather connected with general physicochemical properties.
452
Lipid A: chemical structure and biological activity.
Otto Lüderitz,Chris Galanos,Volker Lehmann,Marjatta Nurminen,Ernst Th. Rietschel,Günter Rosenfelder,Markus M. Simon,Otto Westphal +7 more
TL;DR: Free lipid A, solubilized by complexing with bovine serum albumin, exhibits strong endotoxic activity in a number of biological tests and leads to the production of specific antibodies to lipid A that are capable of cross-reacting with a large variety of lipopolysaccharides.
294