Choon Ping Tan
London Research Institute
5 Papers
1 Citations
Choon Ping Tan is an academic researcher from London Research Institute. The author has contributed to research in topics: RNA silencing & RNA-dependent RNA polymerase. The author has an hindex of 3, co-authored 3 publications. Previous affiliations of Choon Ping Tan include University of Oxford.
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Papers
RIG-I detects viral genomic RNA during negative-strand RNA virus infection.
Jan Rehwinkel,Choon Ping Tan,Choon Ping Tan,Delphine Goubau,Oliver Schulz,Andreas Pichlmair,Katja Bier,Nicole C. Robb,Frank T. Vreede,Wendy S. Barclay,Ervin Fodor,Caetano Reis e Sousa +11 more
TL;DR: It is shown that RIG-I agonists are exclusively generated by the process of virus replication and correspond to full-length virus genomes, and nongenomic viral transcripts, short replication intermediates, and cleaved self-RNA do not contribute substantially to interferon induction in cells infected with these negative strand RNA viruses.
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Control of the DNA Methylation System Component MBD2 by Protein Arginine Methylation
Choon Ping Tan,Sara Nakielny +1 more
TL;DR: This report provides a molecular description of a potential regulatory mechanism for an MBD protein family member and is the first to demonstrate that protein arginine methyltransferases participate in the DNA methylation system of chromatin control.
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850 Interim results for phase 1b dose expansion of MTL-CEBPA in combination with pembrolizumab in patients with advanced solid tumour malignancies
Ruth Plummer,Mikael H. Sodergren,B. Ryan,Ilian Tachkov,Vikash Reebye,Tim Meyer,David J. Pinato,Debashis Sarker,Bristi Basu,Sarah P. Blagden,Natalie Cook,Jeff Evans,Jeffrey Yachnin,Cheng E. Chee,Daneng Li,Anthony B. El-Khoueiry,Maria Diab,Kai-Wen Huang,Antonio D'Alessio,Claudia Angela Maria Fulgenzi,Marcus Smith Noel,Bridget P. Keenan,Devalingam Mahalingam,Nina Raulf,Rose Hogson,Choon Ping Tan,Joanna Nicholls,A. Adderkin,Julia Vassiliadou,Robert H. Habib,John J. Rossi,Nagy A. Habib +31 more
- 01 Nov 2022
TL;DR: In this paper , the authors reported dose escalation data for MTL-CEBPA in combination with ICI from TIMEPOINT, an ongoing multi-centre phase 1/1b study (NCT-04105335).
RIG-I-Mediated Antiviral Responses to Single-Stranded RNA Bearing 5' Phosphates
Andreas Pichlmair,Oliver Schulz,Choon Ping Tan,Tanja I. Näslund,Peter Liljeström,Friedemann Weber,Caetano Reis e Sousa +6 more
TL;DR: It is shown that influenza A virus infection does not generate dsRNA and that RIG-I is activated by viral genomic single-stranded RNA (ssRNA) bearing 5′-phosphates, and suggested that its ability to sense 5'-phosphorylated RNA evolved in the innate immune system as a means of discriminating between self and nonself.