Chong Xu
University of Pennsylvania
4 Papers
6 Citations
Chong Xu is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: T cell & Chimeric antigen receptor. The author has an hindex of 2, co-authored 4 publications.
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Papers
Checkpoint Blockade Reverses Anergy in IL-13Rα2 Humanized scFv-Based CAR T Cells to Treat Murine and Canine Gliomas
Yibo Yin,Yibo Yin,Alina C. Boesteanu,Zev A. Binder,Chong Xu,Reiss A. Reid,Jesse L. Rodriguez,Danielle R. Cook,Radhika Thokala,Kristin Blouch,Bevin McGettigan-Croce,Logan Zhang,Christoph Konradt,Alexandria P. Cogdill,M. Kazim Panjwani,Shuguang Jiang,Denis Migliorini,Nadia Dahmane,Avery D. Posey,Carl H. June,Nicola J. Mason,Zhiguo Lin,Donald M. O'Rourke,Laura A. Johnson +23 more
TL;DR: Two humanized interleukin-13 receptor α2 (IL-13Rα2) chimeric antigen receptors (CARs) were generated and recognized, which will help to inform a human clinical trial design for glioblastoma using humanized scFv-based IL-13rα2 targeting CAR T cells.
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Biochemical and functional characterization of mutant KRAS epitopes validates this oncoprotein for immunological targeting.
Adham S. Bear,Tatiana Blanchard,Joseph Cesare,Michael J. Ford,Lee P. Richman,Chong Xu,Miren L. Baroja,Sarah McCuaig,Christina Costeas,Khatuna Gabunia,John Scholler,Avery D. Posey,Avery D. Posey,Mark H. O'Hara,Smole Anze,Daniel J. Powell,Benjamin A. Garcia,Robert H. Vonderheide,Gerald P. Linette,Beatriz M. Carreno +19 more
TL;DR: In this paper, a multi-omics approach was employed to characterize HLA class I-restricted mutant KRAS epitopes and validate mKRAS peptides as bona fide epitopes facilitating the development of immune therapies targeting this oncoprotein.
CAR T-Cells Depend on the Coupling of NADH Oxidation with ATP Production
Juan Carlos García-Cañaveras,David Heo,Sophie Trefely,John Leferovich,Chong Xu,Benjamin Philipson,Saba Ghassemi,Michael C. Milone,Edmund K. Moon,Nathaniel W. Snyder,Nathaniel W. Snyder,Carl H. June,Joshua D. Rabinowitz,Roddy S. O’Connor +13 more
TL;DR: In this article, the enzyme Lactobacillus brevis NADH Oxidase (LbNOX), which mimics the oxidative function of the electron transport chain without generating ATP, was shown to promote CAR T-cell metabolic activity and antitumor efficacy.
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Abstract B139: Toxicity testing of EGFRvIII CAR-based immunotherapy of glioblastoma: From bench to bedside
Alexandria P. Cogdill,Alina C. Boesteanu,Chong Xu,Kathleen A. Haines,John Scholler,Joseph A. Fraietta,Yangbing Zhao,Xiaojun Liu,Jennifer J.D. Morrissette,Bruce L. Levine,Simon F. Lacey,Andreas Loew,Reshma Singh,Jennifer Brogdon,Donald M. O'Rourke,Marcela V. Maus,Carl H. June,Laura A. Johnson +17 more
TL;DR: A panel of donor-derived primary cells are generated and expanded ex-vivo in to sufficient numbers to utilize as targets for evaluating potential normal tissue toxicity of epidermal growth factor receptor mutation variant three (EGFRvIII)-specific chimeric antigen receptors (CAR) prior to use in clinical trials for patients with glioblastoma.
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