Chong Ock Lee
35 Papers
242 Citations
Chong Ock Lee is an academic researcher. The author has contributed to research in topics: Anaplastic lymphoma kinase & Active ingredient. The author has an hindex of 12, co-authored 35 publications.
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Papers
Induced protein degradation of anaplastic lymphoma kinase (ALK) by proteolysis targeting chimera (PROTAC)
TL;DR: To degrade the anaplastic lymphoma kinase (ALK) fusion protein, such as NPM-ALK or EML4-ALK, several ALK-PROTAC molecules consisted of ceritinib, one of the ALK inhibitors, and ligand of von Hippel-Lindau (VHL) E3 ligase, which effectively induced ALK degradation and inhibited the growth of ALK fusion positive cell lines.
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Folate receptor 1 (FOLR1) targeted chimeric antigen receptor (CAR) T cells for the treatment of gastric cancer
Minsung Kim,Suhkneung Pyo,Chung Hyo Kang,Chong Ock Lee,Heung Kyoung Lee,Sang Un Choi,Chi Hoon Park +6 more
TL;DR: Conclusively, this is the first study to demonstrate that CAR KHYG-1/T cells targeting FOLR1 are effective against F OLR1-positive gastric cancer cells.
Design and characterization of cereblon-mediated androgen receptor proteolysis-targeting chimeras.
Akshay. D. Takwale,Seung-Hyun Jo,Yeong Uk Jeon,Hyung-Soo Kim,Choong Hoon Shin,Heung Kyoung Lee,Sunjoo Ahn,Chong Ock Lee,Jae Du Ha,Jeong Hoon Kim,Jeong Hoon Kim,Jong Yeon Hwang +11 more
TL;DR: The design and biological evaluation of a series of androgen receptor (AR) PROTAC degraders for the treatment of metastatic castration-resistant prostate cancer are reported, and it is shown that TD-802 effectively inhibited tumor growth in an in vivo xenograft study.
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Novel c-Met inhibitor suppresses the growth of c-Met-addicted gastric cancer cells
Chi Hoon Park,Sung Yun Cho,Jae Du Ha,Hee Jung Jung,Hyung Rae Kim,Chong Ock Lee,In-Young Jang,Chong Hak Chae,Heung Kyoung Lee,Sang Un Choi +9 more
TL;DR: In vitro and in vivo data suggest KRC-00715 is a potent and highly selective c-Met inhibitor which may have therapeutic potential in gastric tumor with c-met overexpression.
Discovery of aminopyridines substituted with benzoxazole as orally active c-Met kinase inhibitors.
Sung Yun Cho,Sun-Young Han,Jae Du Ha,Jae Wook Ryu,Chong Ock Lee,Hee Jung Jung,Nam Sook Kang,Hyoung Rae Kim,Jong Sung Koh,Jongkook Lee +9 more
TL;DR: The synthesis and biological evaluation of aminopyridines substituted with benzoxazole led to the discovery of amide 24 which showed good c-Met inhibitory potency, low affinity to hERG and favorable pharmacokinetic properties in rats.
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