Chloe Bramwell
7 Papers
Chloe Bramwell is an academic researcher. The author has contributed to research in topics: Internal medicine & Downregulation and upregulation. The author has an hindex of 1, co-authored 2 publications.
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Papers
FXR inhibition may protect from SARS-CoV-2 infection by reducing ACE2
Teresa Brevini,Mailis Maes,Gwilym J. Webb,Binu John,Claudia D. Fuchs,Gustav Buescher,Lu Wang,Chelsea Griffiths,Marnie Brown,William E. Scott,P. Pereyra-Gerber,William Gelson,Stephanie Brown,Scott Dillon,Daniele Muraro,Joanne Sharp,Megan Neary,Helen Box,Lee Tatham,James P. Stewart,Paul Curley,Henry Pertinez,Sally Forrest,Petra Mlcochova,Sagar S. Varankar,Mahnaz Darvish-Damavandi,Victoria Mulcahy,Rhoda E. Kuc,Thomas L Williams,James A. Heslop,Davide Rossetti,Olivia C. Tysoe,Vasileios Galanakis,Marta Vila-Gonzalez,Thomas W. M. Crozier,Johannes Bargehr,Sanjay Sinha,Sara Upponi,Corrina Fear,Lisa Swift,Kourosh Saeb-Parsy,Susan E. Davies,Axel Wester,Hannes Hagström,Espen Melum,D. K. Clements,Peter Humphreys,Joanne Herriott,Edyta Kijak,Helen Cox,Chloe Bramwell,Anthony J. Valentijn,Christopher J. R. Illingworth,Bassam Dahman,Dustin R Bastaich,Raphaella D. Ferreira,Thomas Marjot,Eleanor Barnes,Andrew M. Moon,A. Sidney Barritt,Ravindra K. Gupta,Stephen Baker,Anthony P. Davenport,G. Corbett,Vassilis G. Gorgoulis,Simon J.A. Buczacki,Joo-Hyeon Lee,Nicholas J Matheson,Michael Trauner,Andrew J. Fisher,Paul Gibbs,Andrew J. Butler,Christopher A. Watson,George F. Mells,Gordon Dougan,Andrew Owen,Ansgar W. Lohse,Ludovic Vallier,Fotios Sampaziotis +78 more
TL;DR: In this article , the authors show that the farnesoid X receptor (FXR) is a direct regulator of ACE2 transcription in several tissues affected by COVID-19, including the gastrointestinal and respiratory systems.
Evaluation of Nafamostat as Chemoprophylaxis for SARS-CoV-2 Infection in Hamsters
Megan Neary,Joanne Sharp,Eduardo Gallardo-Toledo,Joanne Herriott,Edyta Kijak,Chloe Bramwell,Helen Cox,Lee Tatham,Helen Box,Paul Curley,Usman Arshad,Rajith K. R. Rajoli,Henry Pertinez,Anthony J. Valentijn,Kevin Dhaliwal,Frank Mc Caughan,James J. Hobson,Steven Paul Rannard,Anja Kipar,James P. Stewart,Andrew Owen +20 more
TL;DR: Whether intranasal dosing of nafamostat at 5 mg/kg twice daily was able to prevent the airborne transmission of SARS-CoV-2 from infected to uninfected Syrian Golden hamsters is investigated.
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The effect of molnupiravir and nirmatrelvir on SARS-CoV-2 genome diversity in infected and immune suppressed mice
Rebekah Penrice-Randal,Eleanor G. Bentley,Parul Sharma,Adam Kirby,I'ah Donovan-Banfield,Anja Kipar,D. F. Mega,Chloe Bramwell,Joanne Sharp,Andrew Owen,Julian A. Hiscox,James P. Stewart +11 more
TL;DR: The antiviral drugs molnupiravir and nirmatrelvir are effective in reducing viral load and pathological changes in SARS-CoV-2 infected immunosuppressed mice. However, they do not consistently alter the viral consensus sequence, except for the emergence of the S:H655Y mutation.
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Chemoprophylactic Assessment of Combined Intranasal SARS-CoV-2 Polymerase and Exonuclease Inhibition in Syrian Golden Hamsters
Eduardo Gallardo-Toledo,Megan Neary,Joanne Sharp,Joanne Herriott,Edyta Kijak,Chloe Bramwell,Paul Curley,Usman Arshad,Henry Pertinez,Rajith K. R. Rajoli,Anthony Valentijn,Helen Cox,Lee Tatham,Anja Kipar,James P. Stewart,Andrew Owen +15 more
TL;DR: Overall, prevention of transmission was observed in most animals treated with RDV, while other agents reduced the viral load following contact transmission, and no benefit of combining FVP or RDV with PIB was observed.
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Myosin Heavy Chain 9 is Involved in Murine Gammaherpesvirus 68 Infection and as a Drug Target for Antiviral Infection
Ximeng Han,Jordan J. Clark,Parul Sharma,Eleanor G. Bentley,Anja Kipar,Mohammed Alsayer,Xiaolei Ren,A. Robinson,Chloe Bramwell,Adam Kirby,Sondus ALAidarous,Yang Mu,Yani Sun,Julian A. Hiscox,En-Min Zhou,James P. Stewart,Qin Zhao +16 more