Chloe Admane
6 Papers
Chloe Admane is an academic researcher. The author has contributed to research in topics: Gene & Haematopoiesis. The author has an hindex of 1, co-authored 1 publications.
Chat about Author
Papers
Yolk sac cell atlas reveals multiorgan functions during human early development
Issac Goh,Rachel A. Botting,Antony Rose,Simone Webb,Justin Engelbert,Yorick Gitton,Emily Stephenson,Mariana Quiroga Londoño,Michael W. Mather,Nicole Mende,Ivan Imaz-Rosshandler,Lu Yang,Dave Horsfall,Daniela Basurto-Lozada,Nana-Jane Chipampe,Victoria Rook,Jimmy Tsz,H. Lee,Mai-Linh N Ton,Daniel Keitley,Pavel Mazin,Rebecca Hannah,Laure Gambardella,Kile Green,Stephane Ballereau,Megumi Inoue,Elizabeth Tuck,Valentina Lorenzi,Kwasi Kwakwa,Clara Alsinet,Bayanne Olabi,Mohiuddin Miah,Chloe Admane,Dorin Popescu,Meghan Acres,David Dixon,T Ness,Rowen Coulthard,Steven Lisgo,Deborah J. Henderson,Emma Dann,Chenqu Suo,Sarah Kinston,Jong-Eun Park,Krzysztof Polanski,John C. Marioni,S. Dongen,Kerstin B. Meyer,M. D. Bruijn,James Palis,Sam Behjati,Elisa Laurenti,Nicola K. Wilson,Roser Vento-Tormo,Alain Chédotal,Omer Ali Bayraktar,Irene Roberts,Laura Jardine,Berthold Göttgens,Sarah A. Teichmann,Muzlifah Haniffa +60 more
TL;DR: A comprehensive multiomic reference of the extraembryonic yolk sac from 3 to 8 postconception weeks is assembled by integrating single-cell protein and gene expression data and reports that human YS can fuel the accelerated production of macrophages from hematopoietic stem and progenitor cells independently of monocytes.
42
Multi-organ functions of yolk sac during human early development
Rachel A. Botting,Issac Goh,Antony Rose,Simone Webb,Justin Engelbert,Yorick Gitton,Emily Stephenson,Mariana Quiroga Londoño,Michael W. Mather,Nicole Mende,Ivan Imaz-Rosshandler,Dave Horsfall,Daniela Basurto-Lozada,Nana-Jane Chipampe,Victoria Rook,Pavel Mazin,M. S. Vijayabaskar,Rebecca Hannah,Laure Gambardella,Kile Green,Stephane Ballereau,Megumi Inoue,Liz Tuck,Valentina Lorenzi,Kwasi Kwakwa,Clara Alsinet,Bayanne Olabi,Mohiuddin Miah,Chloe Admane,Dorin Popescu,Meghan Acres,David Dixon,Rowen Coulthard,Steven Lisgo,Deborah J. Henderson,Emma Dann,Chenqu Suo,Sarah Kinston,Jong-Eun Park,Krzysztof Polanski,Stijn van Dongen,Kerstin B. Meyer,Marella F. T. R. de Bruijn,James Palis,Sam Behjati,Elisa Laurenti,Nicola K. Wilson,Roser Vento-Tormo,Alain Chédotal,Omer Ali Bayraktar,Irene Roberts,Laura Jardine,Berthold Göttgens,Sarah A. Teichmann,Muzlifah Haniffa +54 more
TL;DR: A complete single cell 3D map of human YS from 3-8 post conception weeks is assembled by integrating multiomic protein and gene expression data revealing the YS as a site of primitive and definitive haematopoiesis including a YS-specific accelerated route to macrophage production, a source of nutritional/metabolic support and a regulator of oxygen-carrying capacity.
Cutaneous T cell lymphoma atlas reveals malignant Th2 cells supported by a B cell-rich microenvironment
Ruoyan Li,Johanna Strobl,Elizabeth Poyner,Fereshteh Torabi,Pasha Mazin,Nana-Jane Chipampe,Emily Stephenson,Louis Gardner,Bayanne Olabi,Rowen Coulthard,Rachel A. Botting,Nina Zila,Elena Prigmore,Nusayhah Gopee,Justin Engelbert,Issac Goh,Hon Man Chan,Harriet Johnson,Jasmine Ellis,Vicky Rowe,Win Tun,Gary Reynolds,April Rose Foster,L. Gambardella,Elena Winheim,Chloe Admane,Ben Rumney,Lloyd Steele,Laura Jardine,Julia Nenonen,Keir Pickard,Jennifer Lumley,Philip Hampton,Simeng Hu,Fengjie Liu,Xiangjun Liu,Dave Horsfall,Daniela Basurto-Lozada,Louise Grimble,Chris M. Bacon,S. Weatherhead,Hanna Brauner,Yang Wang,Fan Bai,Nick J. Reynolds,Judith E. Allen,Constanze Jonak,Patrick M Brunner,Sara A Teichmann,Muzlifah Haniffa +49 more
TL;DR: This work reveals the co-optation of Th2-immune gene programmes by malignant CTCL cells and modelling of the tumour microenvironment to support their survival, and identifies MHC-II+ fibroblast subsets reminiscent of lymph node T-zone reticular cells and monocyte-derived dendritic cells that can maintain Th1-like tumour cells.
1
O13 Benchmarking a human pluripotent stem cell-derived hair-bearing skin organoid model to prenatal skin
L. Gambardella,Feri Torabi,A. Foster,Chloe Admane,Elena Winheim,Nusayhah Gopee,B. Olabi,Vicky Rowe,Dinithi Sumanaweera,Phuong Ahn Le,Sara A. Serdy,Jin Kim,CiCi Deakin,Jiyoon Lee,Emily Stephenson,R. Botting,Karl Koehler,Sarah Teichmann,Muzlifah Haniffa +18 more
TL;DR: A human pluripotent stem cell-derived hair-bearing skin organoid model recapitulates prenatal skin development and provides insights into hair follicle formation and congenital skin disorders.
O12 Macrophages enhance angiogenesis in an induced pluripotent stem cell-derived skin organoid model
A. Foster,Chloe Admane,Diana Adao,Fereshteh Torabi,Nusayhah Gopee,B. Olabi,Elena Winheim,Vicky Rowe,Phuong Ahn Le,Sara A. Serdy,Jin Kim,CiCi Deakin,Jiyoon Lee,Tong Li,Karl Koehler,L. Gambardella,Muzlifah Haniffa +16 more
TL;DR: O12 macrophages enhance angiogenesis in an induced pluripotent stem cell-derived skin organoid model, highlighting their crucial role in skin development and vasculature formation.