In reaction to the marketing suspension recommended by the European Medicines Agency, Genentech announced the voluntary withdrawal of efalizumab. Since June 8, 2009, efalizumab has been unavailable. Despite the fact that the use of efalizumab is now ceased, results of studies with efalizumab will remain relevant, especially about its use in an off-label setting for indications other then chronic plaque psoriasis. New biologics as well as chemicals are being developed targeting similar T-cell-mediated pathways. Indications for these new compounds other than chronic plaque psoriasis could be selected based on this systematic review. With this article we aimed to summarize the evidence of effectiveness and/or the efficacy and safety of efalizumab in off-label dermatological use, and to illustrate the time scale in which dermatological medicines are offered off-label to dermatological patients. We found some evidence supporting the effectiveness of efalizumab in palmoplantar pustulosis, atopic dermatitis, lic...

Off-label use of efalizumab in dermatology

/pdf/massive-pyoderma-gangrenosum-in-a-77-year-old-female-with-jng3ukprpr.pdf

Massive pyoderma gangrenosum in a 77 year old female with Crohn's disease responsive to adalimumab.

Eczeem komt vaker voor in steden dan op het platteland. Dit resultaat van het onderzoek van Mandy Schram is een bevestiging van de zogeheten hygiene-hypothese. Ze vergeleek ook twee middelen methotrexaat en azathioprine voor de behandeling van ernstig eczeem. Beide zijn even effectief en veilig. Bij twee geneesmiddelen (efalizumab en azathioprine) is gezocht naar bewijs voor off-label- toepassing bij huidziekte. Dit is belangrijk vanwege nieuwe regelgeving op het gebied van off-label voorschrijven van medicatie.

/pdf/atopic-dermatitis-epidemiology-off-label-therapy-3kij6kpqg7.pdf

Atopic dermatitis: epidemiology & off-label therapy

Off-label use of efalizumab

Anti-TNF therapy: Is this our answer to pyoderma gangrenosum

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Anti-TNF therapy: Is this our answer to pyoderma gangrenosum