Chika Okusa
Osaka Dental University
8 Papers
17 Citations
Chika Okusa is an academic researcher from Osaka Dental University. The author has contributed to research in topics: Cardioprotection & Sevoflurane. The author has an hindex of 5, co-authored 7 publications. Previous affiliations of Chika Okusa include Albert Einstein Medical Center.
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Papers
Sevoflurane Enhances Ethanol-Induced Cardiac Preconditioning Through Modulation of Protein Kinase C, Mitochondrial KATP Channels, and Nitric Oxide Synthase, in Guinea Pig Hearts
Kazuhiro Kaneda,Masami Miyamae,Shingo Sugioka,Chika Okusa,Yoshitaka Inamura,Naochika Domae,Junichiro Kotani,Vincent M. Figueredo +7 more
TL;DR: Sevoflurane enhances cardiac preconditioning induced by regular EtOH consumption and this effect is mediated in part by modulation of PKC and mitochondrial KATP channels, and possibly by altered modulation of NOS expression.
Aprotinin Abolishes Sevoflurane Postconditioning by Inhibiting Nitric Oxide Production and Phosphorylation of Protein Kinase C-δ and Glycogen Synthase Kinase 3β
Yoshitaka Inamura,Masami Miyamae,Shingo Sugioka,Kazuhiro Kaneda,Chika Okusa,Anna Onishi,Naochika Domae,Junichiro Kotani,Vincent M. Figueredo +8 more
TL;DR: Aprotinin abolishes sevoflurane postconditioning, associated with inhibited phosphorylation of Akt, protein kinase C-&dgr;, and glycogen synthase kinase 3β and reduced nitric oxide production.
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Acute memory phase of sevoflurane preconditioning is associated with sustained translocation of protein kinase C-α and ε, but not δ, in isolated guinea pig hearts
Chika Okusa,Masami Miyamae,Shingo Sugioka,Kazuhiro Kaneda,Yoshitaka Inamura,Anna Onishi,Naochika Domae,Junichiro Kotani,Vincent M. Figueredo +8 more
TL;DR: The acute memory phase of sevoflurane preconditioning is limited to less than 60 min, and sustained translocation of PKC-α and ϵ, but not δ, was associated with the time frame of the acute memoryphase.
Sevoflurane confers additive cardioprotection to ethanol preconditioning associated with enhanced phosphorylation of glycogen synthase kinase-3β and inhibition of mitochondrial permeability transition pore opening.
Anna Onishi,Masami Miyamae,Hiroshi Inoue,Kazuhiro Kaneda,Chika Okusa,Yoshitaka Inamura,Mayumi Shiomi,Shizuka Koshinuma,Yoshihiro Momota,Vincent M. Figueredo +9 more
TL;DR: SEVO and chronic EtOH preconditioning offer additive cardioprotection and this effect is associated with an increased GSK-3β phosphorylation and an inhibition of MPTP opening.
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Regular dipyridamole therapy produces sustained protection against cardiac ischemia–reperfusion injury: Is it time to revisit PARIS?
Vincent M. Figueredo,Vincent M. Figueredo,Chika Okusa,Kazuhiro Kaneda,Yoshitaka Inamura,Masami Miyamae +5 more
TL;DR: A chronic preconditioning-like cardioprotection by regular dipyridamole treatment persists for 3 days after discontinuing therapy, and increased activated Akt and eNOS expression may play a role in this persistent cardioprotsection.
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