Chihiro Mogi
Gunma University
51 Papers
144 Citations
Chihiro Mogi is an academic researcher from Gunma University. The author has contributed to research in topics: Receptor & Extracellular. The author has an hindex of 27, co-authored 49 publications.
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Papers
TDAG8 Is a Proton-sensing and Psychosine-sensitive G-protein-coupled Receptor
Ju-Qiang Wang,Junko Kon,Chihiro Mogi,Masayuki Tobo,Alatangaole Damirin,Koichi Sato,Mayumi Komachi,Enkhzol Malchinkhuu,Naoya Murata,Takao Kimura,Atsushi Kuwabara,Kaori Wakamatsu,Hideki Koizumi,Toshimitsu Uede,Gozoh Tsujimoto,Hitoshi Kurose,Takashi Sato,Akihiro Harada,Norihiko Misawa,Hideaki Tomura,Fumikazu Okajima +20 more
TL;DR: T cell death-associated gene 8 is one of the proton-sensing GPCRs coupling to adenylyl cyclase and psychosine, and its related lysosphingolipids behave as if they were antagonists against protein-s sensing receptors, including TDAG8, GPR4, and OGR1.
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Role of scavenger receptor class B type I and sphingosine 1-phosphate receptors in high density lipoprotein-induced inhibition of adhesion molecule expression in endothelial cells.
Takao Kimura,Hideaki Tomura,Chihiro Mogi,Atsushi Kuwabara,Alatangaole Damirin,Tamotsu Ishizuka,Akihiro Sekiguchi,Mitsuteru Ishiwara,Doon-Soon Im,Koichi Sato,Masami Murakami,Fumikazu Okajima +11 more
TL;DR: Even though S 1P alone stimulates adhesion molecule expression, HDL overcomes S1P3 receptor-mediated stimulatory actions through SR-BI/PDZK1-mediated signaling pathways involving phosphatidylinositol 3-kinase and NOS.
210
Critical role of ABCA1 transporter in sphingosine 1-phosphate release from astrocytes.
Koichi Sato,Enkhzol Malchinkhuu,Yuta Horiuchi,Chihiro Mogi,Hideaki Tomura,Masahiko Tosaka,Yuhei Yoshimoto,Atsushi Kuwabara,Fumikazu Okajima +8 more
TL;DR: The treatment of rat astrocytes with retinoic acid and dibutyryl cAMP stimulated extracellular S1P accumulation in the presence of its precursor sphingosine, and it is concluded that the S 1P release from astroCytes is coupled with lipoprotein formation through ABCA1.
198
Involvement of proton-sensing TDAG8 in extracellular acidification-induced inhibition of proinflammatory cytokine production in peritoneal macrophages.
Chihiro Mogi,Masayuki Tobo,Hideaki Tomura,Naoya Murata,Xiao-dong He,Koichi Sato,Takao Kimura,Tamotsu Ishizuka,Takehiko Sasaki,Takashi Sato,Yasuyuki Kihara,Satoshi Ishii,Akihiro Harada,Fumikazu Okajima +13 more
TL;DR: It is concluded that TDAG8, at least partly, mediates the extracellular acidification-induced inhibition of proinflammatory cytokine production through the Gs protein/cAMP/PKA signaling pathway in mouse macrophages.
Previously postulated "ligand-independent" signaling of GPR4 is mediated through proton-sensing mechanisms.
Masayuki Tobo,Hideaki Tomura,Chihiro Mogi,Ju Qiang Wang,Jin Peng Liu,Mayumi Komachi,Alatangaole Damirin,Takao Kimura,Naoya Murata,Hitoshi Kurose,Koichi Sato,Fumikazu Okajima +11 more
TL;DR: GPR4 may be a multi-functional receptor coupling to Gs, G13, and Gq/11 proteins in response to extracellular acidification and play a role as a ligand in some of previously postulated ligand-independent actions through GPR4 receptors.
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