Chie Santis
National Institutes of Health
7 Papers
90 Citations
Chie Santis is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Melanin & Macrophage migration inhibitory factor. The author has an hindex of 7, co-authored 7 publications.
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Papers
Inhibitors of mammalian melanocyte tyrosinase: in vitro comparisons of alkyl esters of gentisic acid with other putative inhibitors
Ernest V. Curto,Cecil D. Kwong,Heino Hermersdörfer,Hansruedi Glatt,Chie Santis,Victoria M. Virador,Vincent J. Hearing,Thomas P. Dooley +7 more
TL;DR: The properties of MG in vitro, including pigmentation inhibition in melanocytes, tyrosinase inhibition and selectivity, reduced cytotoxicity relative to HQ, and lack of mutagenic potential in mammalian cells, establish MG as a superior candidate skin-lightening agent.
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Enzyme activity of macrophage migration inhibitory factor toward oxidized catecholamines
Jun Matsunaga,Debasish Sinha,Lew Pannell,Chie Santis,Francisco Solano,Graeme Wistow,Vincent J. Hearing +6 more
TL;DR: It is shown that MIF is able to catalyze the conversion of 3,4-dihydroxyphenylaminechrome and norepinephrinechrome, toxic quinone products of the neurotransmitter catecholamines, to indoledihydroxy derivatives that may serve as precursors to neuromelanin.
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Normal tyrosine transport and abnormal tyrosinase routing in pink-eyed dilution melanocytes.
S B Potterf,Minao Furumura,Elena V. Sviderskaya,Chie Santis,Dorothy C. Bennett,Vincent J. Hearing +5 more
TL;DR: Melan-p1 cells, more differentiated pink-eyed dilution melanocytes which can be induced to produce melanin, are utilized, to characterize the melanogenic lesion(s) more definitively and indicate that this protein may serve a chaperone-like or stabilizing function in melanocytes.
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Cysteine transport in melanosomes from murine melanocytes.
S B Potterf,Victoria M. Virador,Kazumasa Wakamatsu,Minao Furumura,Chie Santis,Shosuke Ito,Vincent J. Hearing +6 more
TL;DR: This study shows that cysteine is transported, in a temperature- and concentration-dependent manner, across membranes of melanosomes derived from murine melanocytes, and strongly suggests that free cy steine is the thiol source utilized for pheomelanin synthesis in mammalian melanocytes.
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•Journal Article
Macrophage migration inhibitory factor (MIF)--its role in catecholamine metabolism.
TL;DR: It is shown that MIF is able to catalyze the conversion of dopaminechrome and norepinephrinechrome, toxic quinone products of the neurotransmitters dopamine and norpinephrine, respectively, to indole derivatives that may serve as precursors to neuromelanin.
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