Chie Hotta
Yokohama City University
9 Papers
128 Citations
Chie Hotta is an academic researcher from Yokohama City University. The author has contributed to research in topics: Antigen presentation & Antigen processing. The author has an hindex of 8, co-authored 9 publications. Previous affiliations of Chie Hotta include Yokohama City University Medical Center.
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Papers
The delivery of an antigen from the endocytic compartment into the cytosol for cross-presentation is restricted to early immature dendritic cells
TL;DR: Differences in cross‐presentation ability among murine bone marrow‐derived immature DC, early immature day8‐DC and late immature day10‐DC, and fully mature day10 + lipopolysaccharide DC are reported.
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Anti-Semaphorin 3A neutralization monoclonal antibody prevents sepsis development in lipopolysaccharide-treated mice.
Naoya Yamashita,Aoi Jitsuki-Takahashi,Miyuki Ogawara,Wataru Ohkubo,Tomomi Araki,Chie Hotta,Tomohiko Tamura,Shu-ichi Hashimoto,Takashi Yabuki,Toru Tsuji,Sasakura Yukie,Hiromi Okumura,Aki Takaiwa,Chika Koyama,Koji Murakami,Yoshio Goshima +15 more
TL;DR: It is found that the anti-Sema3A antibodies were effective for improving the survival rate in lipopolysaccharide-induced sepsis in mice and is a potential therapeutic agent that may prevent the onset of or alleviate symptoms of human diseases associated with Sema 3A.
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Impaired function of dendritic cells in alymphoplasia (aly/aly) mice for expansion of CD25+CD4+ regulatory T cells.
Chizuru Tamura,Masatoshi Nakazawa,Masaki Kasahara,Chie Hotta,Masahiro Yoshinari,Fumitaka Sato,Mutsuhiko Minami +6 more
TL;DR: The results suggested that the impairment of DCs in aly/aly mice is responsible, at least in part, for the decreased numbers of CD25+CD4+T cells in the periphery of aly /aly mice.
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The transcription factor IRF8 counteracts BCR-ABL to rescue dendritic cell development in chronic myelogenous leukemia.
Tomoya Watanabe,Chie Hotta,Shin ichi Koizumi,Kazuho Miyashita,Jun Nakabayashi,Daisuke Kurotaki,Go R. Sato,Michio Yamamoto,Masatoshi Nakazawa,Hiroyuki Fujita,Rika Sakai,Shin Fujisawa,Akira Nishiyama,Zenro Ikezawa,Michiko Aihara,Yoshiaki Ishigatsubo,Tomohiko Tamura +16 more
TL;DR: It is shown that BCR-ABL strongly inhibits a generation of dendritic cells from an early stage of their differentiation in vivo, concomitant with suppression of Irf8 expression, suggesting that IRF8 is an attractive target in next-generation therapies for CML.
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Human invariant Vα24+ natural killer T cells acquire regulatory functions by interacting with IL-10-treated dendritic cells
TL;DR: It is demonstrated that tolerogenic DCs (tolDCs), generated by treatment of monocyte-derived DC with interleukin (IL)-10, induced regulatory functions in human iN KT cells and anergic Valpha24(+) iNKT cells were able to potently inhibit allogeneic CD4(+) T-cell proliferation in vitro.
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