Chiara Fedeli
University of Padua
14 Papers
57 Citations
Chiara Fedeli is an academic researcher from University of Padua. The author has contributed to research in topics: Medicine & Chemistry. The author has an hindex of 7, co-authored 10 publications.
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Papers
C1q-Mediated Complement Activation and C3 Opsonization Trigger Recognition of Stealth Poly(2-methyl-2-oxazoline)-Coated Silica Nanoparticles by Human Phagocytes.
Regina Tavano,Luca Gabrielli,Elisa Lubian,Chiara Fedeli,Silvia Visentin,Silvia Visentin,Patrizia Polverino de Laureto,Giorgio Arrigoni,Alessandra Geffner-Smith,Fangfang Chen,Fangfang Chen,Dmitri Simberg,Giulia Morgese,Edmondo M. Benetti,Lin-Ping Wu,Lin-Ping Wu,Seyed Moein Moghimi,Seyed Moein Moghimi,Fabrizio Mancin,Emanuele Papini +19 more
TL;DR: It is shown that PMOXA-coated NPs extensively trigger complement activation in human sera exclusively through the classical pathway, providing important insights into compatibility of engineered NPs with elements of the human innate immune system for translational steps.
PSEN2 (presenilin 2) mutants linked to familial Alzheimer disease impair autophagy by altering Ca2+ homeostasis
TL;DR: The data sustain the pivotal role for Ca2+ signaling in autophagy and reveal a novel mechanism by which FAD-linked presenilins alter the degradative process, reinforcing the view of a causative role for a dysfunctional quality control pathway in AD neurodegeneration.
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The functional dissection of the plasma corona of SiO₂-NPs spots histidine rich glycoprotein as a major player able to hamper nanoparticle capture by macrophages.
Chiara Fedeli,Daniela Segat,Regina Tavano,Luigi Bubacco,Giorgia De Franceschi,Patrizia Polverino de Laureto,Elisa Lubian,Francesco Selvestrel,Fabrizio Mancin,Emanuele Papini +9 more
TL;DR: Histidine Rich Glycoprotein (HRG) is the most abundant component of the SiO2-NP hard corona in excess plasma from humans (HP) and mice (MP), together with minor amounts of the homologous Kininogen-1 (Kin-1), while it is remarkably absent in their Foetal Calf Serum (FCS)-derived corona.
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Impact on HIV-1 RNA Levels and Antibody Responses Following SARS-CoV-2 Vaccination in HIV-Infected Individuals
Vera Portillo,Chiara Fedeli,Pilar Ustero Alonso,Ianis Petignat,Ellen Cristina Mereles Costa,Adi Sulstarova,Cyril Jaksic,Sabine Yerly,Alexandra Calmy +8 more
TL;DR: All participants elicited antibodies after two doses of mRNA vaccines, with only a minor impact on HIV-1 RNA levels over a 6-month period.
Targeted delivery of photosensitizers: efficacy and selectivity issues revealed by multifunctional ORMOSIL nanovectors in cellular systems
Francesco Selvestrel,Francesca Moret,Daniela Segat,Josephine H. Woodhams,Giulio Fracasso,Iria M. Rio Echevarria,Luca Bau,Federico Rastrelli,Chiara Compagnin,Elena Reddi,Chiara Fedeli,Emanuele Papini,Regina Tavano,Alexandra Mackenzie,Melissa J. Bovis,Elnaz Yaghini,Alexander J. MacRobert,Silvia Zanini,Anita Boscaini,Marco Colombatti,Fabrizio Mancin +20 more
TL;DR: It is shown that selective photokilling of tumour cells may be limited even in the case of efficient targeting because of intrinsic transport limitations of active cellular uptake mechanisms or suboptimum localization.