16 Papers
341 Citations
Chi Luo is an academic researcher from Johnson & Johnson Pharmaceutical Research and Development. The author has contributed to research in topics: Chemical synthesis & Thiocyanate. The author has an hindex of 8, co-authored 16 publications. Previous affiliations of Chi Luo include Janssen Pharmaceutica & Johnson & Johnson.
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Papers
Efficient conversion of substituted aryl thioureas to 2-aminobenzothiazoles using benzyltrimethylammonium tribromide
TL;DR: It is shown here that benzyltrimethylammonium tribromide (1, PhCH2NMe3Br3) can be readily utilized as an alternative electrophilic bromine source and easier to control the stoichiometry of addition with an OATB, which minimizes aromatic bromination caused by excess reagent.
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Patent
Amino pyrazole derivatives useful for the treatment of obesity and other disorders
Cheryl P. Kordik,Scott L. Dax,Chi Luo,Reitz Allen B,Mcnally James J,Timothy W. Lovenberg +5 more
- 23 Feb 2001
TL;DR: Amino pyrazole derivatives of the formula (I) which are ligands for the neuropeptide Y, subtype 5 receptor and pharmaceutical compositions containing an amino prazole derivative as the active ingredient are described in this paper.
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Aminopyrazoles with high affinity for the human neuropeptide Y5 receptor.
Cheryl P. Kordik,Chi Luo,Brian C. Zanoni,Scott L. Dax,Mcnally James J,Timothy W. Lovenberg,Sandy J. Wilson,Allen B. Reitz +7 more
TL;DR: 1,3-Disubstituted-5-aminopyrazoles were prepared based on a lead compound found through high-throughput screening of the authors' corporate compound library in an assay measuring affinity for the human neuropeptide Y5 receptor.
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Pyrazolecarboxamide human neuropeptide Y5 receptor ligands with in vivo antifeedant activity.
Cheryl P. Kordik,Chi Luo,Brian C. Zanoni,Timothy W. Lovenberg,Sandy J. Wilson,Anil H. Vaidya,Jeffrey Crooke,Daniel I. Rosenthal,Allen B. Reitz +8 more
TL;DR: 1-Aryl-3-carboxamido-5-alkylpyrazole bound to the human neuropeptide Y5 receptor with a 80 nM IC(50) and was shown to inhibit cumulative food consumption 43.2% 2-6 h after ip dosing in a fasting-induced feeding model in rats.
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Synthesis of (−)-5,8-Dihydroxy-3R-methyl-2R-(dipropylamino)-1,2,3,4-tetrahydronaphthalene: An Inhibitor of β-Amyloid1–42 Aggregation
Michael H. Parker,Chen Robert H,Kelly A. Conway,Daniel H. S. Lee,Chi Luo,Robert E. Boyd,Samuel O Nortey,Tina Morgan Ross,Malcolm K. Scott,Allen B. Reitz +9 more
TL;DR: Hydroquinone is a potent inhibitor of the fibrillar aggregation of beta-amyloid as determined in two different assay systems.
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