Cheun-Chen Shen
University of South Alabama
2 Papers
43 Citations
Cheun-Chen Shen is an academic researcher from University of South Alabama. The author has contributed to research in topics: DNA damage & DNA repair. The author has an hindex of 2, co-authored 2 publications.
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Papers
Glial cell type-specific responses to menadione-induced oxidative stress.
Scott B. Hollensworth,Cheun-Chen Shen,Julia E. Sim,Douglas R. Spitz,Glenn L. Wilson,Susan P. LeDoux +5 more
TL;DR: The results show that the differential susceptibility of glial cell types to menadione-induced oxidative stress and apoptosis appears to correlate with increased oxidative mt DNA damage and support the hypothesis that mtDNA damage could participate in the initiation of apoptosis.
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Glial cell-specific differences in response to alkylation damage.
Susan P. LeDoux,Cheun-Chen Shen,Valentina I. Grishko,Phillip A. Fields,Anthony L. Gard,Glenn L. Wilson +5 more
TL;DR: A correlation between diminished mtDNA repair capacity and the induction of apoptosis is demonstrated, however, further experimentation is necessary to determine if a causal relationship exists and contributes to the vulnerability of oligodendroglia following exposure to N‐nitroso compounds in the environment or in chemotherapeutic regimen.
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