Chester E. Chamberlain
University of California, San Francisco
20 Papers
182 Citations
Chester E. Chamberlain is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Biology & Medicine. The author has an hindex of 14, co-authored 17 publications. Previous affiliations of Chester E. Chamberlain include Scripps Research Institute & Harvard University.
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Papers
Notochord-derived Shh concentrates in close association with the apically positioned basal body in neural target cells and forms a dynamic gradient during neural patterning
TL;DR: This study genetically engineered mice to produce bioactive, fluorescently labeled Shh from the endogenous locus, and shows that Shh ligand concentrates in close association with the apically positioned basal body of neural target cells, forming a dynamic, punctate gradient in the ventral neural tube.
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Spatial and Temporal Analysis of Rac Activation during Live Neutrophil Chemotaxis
Elisabeth Gardiner,Kersi Pestonjamasp,Benjamin P. Bohl,Chester E. Chamberlain,Klaus M. Hahn,Gary M. Bokoch +5 more
TL;DR: Data establish that Rac GTPase is spatially and temporally regulated to coordinate leading-edge extension and tail retraction during a complex motile response, the chemotaxis of human neutrophils.
192
Human pancreatic neuro-insular network in health and fatty infiltration.
Shiue-Cheng Tang,Luc Baeyens,Chia-Ning Shen,Shih-Jung Peng,Hung-Jen Chien,David W. Scheel,Chester E. Chamberlain,Michael S. German +7 more
TL;DR: It is strongly suggested that fatty infiltration in the human pancreas creates a neurotrophic microenvironment and promotes remodelling of pancreatic innervation via 3D histology.
Menin determines K-RAS proliferative outputs in endocrine cells
Chester E. Chamberlain,David W. Scheel,Kathleen McGlynn,Hail Kim,Takeshi Miyatsuka,Juehu Wang,Vinh Son Nguyen,Shuhong Zhao,Anastasia Mavropoulos,Aswin George Abraham,Eric O'Neill,Gregory M. Ku,Melanie H. Cobb,Gail R. Martin,Michael S. German +14 more
TL;DR: It is found that K-RAS paradoxically suppressed, rather than promoted, growth in pancreatic endocrine cells, and potential strategies both for regenerating pancreatic β cells for people with diabetes and for targeting menin-sensitive endocrine tumors are suggested.
Watching Proteins in the Wild: Fluorescence Methods to Study Protein Dynamics in Living Cells
TL;DR: Next generation approaches enabling not only the visualization of protein movements, but correlation of a protein's dynamics with its changing structural state or ligand binding are developed.
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