Chenxia Hao
Shanghai Jiao Tong University
12 Papers
13 Citations
Chenxia Hao is an academic researcher from Shanghai Jiao Tong University. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 3, co-authored 10 publications.
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Papers
Shikonin induces tumor apoptosis in glioma cells via endoplasmic reticulum stress, and Bax/Bak mediated mitochondrial outer membrane permeability.
TL;DR: Anti-glioma effect of Shikonin by interfering endoplasmic reticulum stress-mediated tumor apoptosis targeting Caspase-3, and Bax/Bak-induced mitochondrial outer membrane permeabilization (MOMP) triggering cancer cell apoptosis.
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Investigation into molecular mechanisms and high-frequency core TCM for pulmonary fibrosis secondary to COVID-19 based on network pharmacology and data mining.
TL;DR: Wang et al. as discussed by the authors identified the cytokines-related molecular mechanisms of PF secondary to COVID-19, and the high-frequency core TCM against PF by targeting IL-6, TNF, and IL-1s.
Compound XiongShao Capsule ameliorates streptozotocin-induced diabetic peripheral neuropathy in rats via inhibiting apoptosis, oxidative - nitrosative stress and advanced glycation end products.
TL;DR: CXSC exerted neuroprotective effects against rats with DPN through multidimensional pharmacological mechanisms including antiapoptotic activity in the sciatic nerve and downregulation of the level of serum NOS, SOD and AGEs, and enhanced antioxidant enzyme SOD activities in the serum.
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Identifying Drug-Induced Liver Injury Associated With Inflammation-Drug and Drug-Drug Interactions in Pharmacologic Treatments for COVID-19 by Bioinformatics and System Biology Analyses: The Role of Pregnane X Receptor
Jingjing Huang,Zhaokang Zhang,Chenxia Hao,Yuzhen Qiu,Ruoming Tan,Jialin Liu,Xiaoli Wang,Wanhua Yang,Hong-Ping Qu +8 more
TL;DR: This study showed the pivotal role of PXR associated with inflammation-drug and drug-drug interactions on DILI and highlighted the cautious clinical decision-making for pharmacotherapy to avoid DILi in the treatment of COVID-19 patients.
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Identifying Synergistic Mechanisms of Multiple Ingredients in Shuangbai Tablets against Proteinuria by Virtual Screening and a Network Pharmacology Approach
TL;DR: Functional enrichment analysis indicated that the most relevant disease including these 48 candidate proteins is proteinuria, and key targets, major active ingredients, and pathways based on data analysis of SBT against proteinuria were systematically identified confirming its utility and providing a new drug againstproteinuria.