Chenshan Lian
Peking University
19 Papers
11 Citations
Chenshan Lian is an academic researcher from Peking University. The author has contributed to research in topics: Chemistry & Medicine. The author has an hindex of 4, co-authored 7 publications.
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Papers
A Sulfonium Triggered Thiol-yne Reaction for Cysteine Modification.
Zhanfeng Hou,Dongyuan Wang,Dongyuan Wang,Yang Li,Rongtong Zhao,Chuan Wan,Yue Ma,Chenshan Lian,Feng Yin,Zigang Li +9 more
TL;DR: A facile thiol-yne type reaction triggered by sulfonium center is reported, which could enable a facile intramolecular addition to construct cyclic peptides with better stability, good glutathione resistance and increased cellular uptakes.
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Histidine-specific bioconjugation via visible-light-promoted thioacetal activation
Chuan Wan,Yuena Wang,Chenshan Lian,Qi Chang,Yuhao An,Jiean Chen,Jinming Sun,Zhanfeng Hou,Dongyan Yang,Xiaochun Guo,Feng Yin,Rui Wang,Zigang Li +12 more
TL;DR: A novel visible-light-driven thioacetal activation reaction which enables facile modification on histidine residues and greatly expands the chemo-selective toolbox for histidine-targeted protein conjugation and helps to reveal histidine's role in protein functions.
Directional assembly of a stapled α-helical peptide.
Kuan Hu,Feng Yin,Ziyuan Zhou,Ziyuan Zhou,Chenshan Lian,Yinghuan Liu,Chengjie Sun,Wenjun Li,Jianing Zhang,Zigang Li +9 more
TL;DR: The development of an oxidation trigger for peptide stapling and subsequent self-assembly is described here and it is shown that these assembled materials can transport siRNA into cancer cells and immediately release the cargo in a reductive environment.
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Sulfonium-Driven Neoantigen-Released DNA Nanodevice as a Precise Vaccine for Tumor Immunotherapy and Prevention.
Yaping Zhang,Hongkun Xu,Leying Jiang,Zhaodi Liu,Chenshan Lian,Xiaofen Ding,Chuan Wan,Na Liu,Yuena Wang,Zhiqiang Yu,Lizhi Zhu,Feng Yin,Zigang Li +12 more
TL;DR: In this article , a peptide-nucleic acid conjugate was prepared, which was driven by a propargyl sulfonium-based efficient and reversible bio-orthogonal reaction under weakly alkaline conditions, and folded into regular DNA nanodevice vaccines.
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Selective Protein of Interest Degradation through the Split-and-Mix Liposome Proteolysis Targeting Chimera Approach.
Chunli Song,Zijun Jiao,Zhanfeng Hou,Rui Wang,Chenshan Lian,Yun Xing,Qinhong Luo,Yuhao An,Fenfang Yang,Yuechen Wang,Xinrui Sha,Zhijun Ruan,Yuxin Ye,Zhi Liu,Zigang Li,Feng Yin +15 more
TL;DR: A novel split-and-mix PROTAC system based on liposome self-assembly, concurrent with modification of FA (folate) to enhance its tumor-targeting capabilities and shows a higher drug efficacy, which offers promising potential applications for PROTAC and other biomolecule regulations.
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