Chenguang Wang
Johns Hopkins University
245 Papers
1.1K Citations
Chenguang Wang is an academic researcher from Johns Hopkins University. The author has contributed to research in topics: Cyclin D1 & Biology. The author has an hindex of 63, co-authored 211 publications. Previous affiliations of Chenguang Wang include Nankai University & University of Washington.
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Papers
Human breast cancer-associated fibroblasts (CAFs) show caveolin-1 downregulation and RB tumor suppressor functional inactivation: Implications for the response to hormonal therapy
Isabelle Mercier,Mathew C. Casimiro,Chenguang Wang,Anne L. Rosenberg,Judy N. Quong,Alimatou Minkeu,Kathleen G. Allen,Christiane Danilo,Federica Sotgia,Gloria Bonuccelli,Jean-Francois Jasmin,Huan Xu,Emily E. Bosco,Bruce J. Aronow,Agnieszka K. Witkiewicz,Richard G. Pestell,Erik S. Knudsen,Michael P. Lisanti +17 more
TL;DR: It is demonstrated that 8 out of 11 CAFs show dramatic down-regulation of caveolin-1 (Cav-1) protein expression; Cav-1 is a well-established marker that is normally decreased during the oncogenic transformation of fibroblasts.
Cyclin D1/Cyclin-Dependent Kinase 4 Interacts with Filamin A and Affects the Migration and Invasion Potential of Breast Cancer Cells
Zhijiu Zhong,Wen-Shuz Yeow,Chunhua Zou,Richard Wassell,Chenguang Wang,Richard G. Pestell,Judy N. Quong,Andrew A. Quong +7 more
TL;DR: Using mass spectrometry, it is found that cyclin D1 and FLNa coimmunoprecipitate and that lower levels of cyclIn D1 are associated with decreased phosphorylation of FLNa at Ser2152 and Ser1459 and many proteins related to cytoskeletal function, biomolecular synthesis, organelle biogenesis, and calcium regulation are identified.
The Dachshund gene in development and hormone-responsive tumorigenesis.
Vladimir M. Popov,Kongming Wu,Jie Zhou,Michael J. Powell,Graeme Mardon,Chenguang Wang,Richard G. Pestell +6 more
TL;DR: The dachshund (dac) gene was initially described as a mutant phenotype in flies featuring extremely short legs relative to their body length but recent studies have demonstrated an important role for human DACH1 in tumorigenesis, in particular, breast, prostate and ovarian cancer.
Transcription elongation regulator 1 is a co-integrator of the cell fate determination factor Dachshund homolog 1.
Jie Zhou,Yang Liu,Yang Liu,Wei Zhang,Vladimir M. Popov,Min Wang,Nagarajan Pattabiraman,Carlos Suñé,Ales Cvekl,Kongming Wu,Jie Jiang,Chenguang Wang,Richard G. Pestell +12 more
TL;DR: DACH1 repressed, whereas FOX proteins enhanced, both DRE and FOXA-responsive element-driven gene expression, and reduced DACH1 expression using a shRNA approach enhanced FOX protein activity.