Chenguang Wang
Johns Hopkins University
245 Papers
1.1K Citations
Chenguang Wang is an academic researcher from Johns Hopkins University. The author has contributed to research in topics: Cyclin D1 & Biology. The author has an hindex of 63, co-authored 211 publications. Previous affiliations of Chenguang Wang include Nankai University & University of Washington.
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Papers
The extracellular matrix and focal adhesion kinase signaling regulate cancer stem cell function in pancreatic ductal adenocarcinoma.
Asma Begum,Theodore Ewachiw,Clinton Jung,Ally Huang,K. Jessica Norberg,Luigi Marchionni,Ross McMillan,Vesselin R. Penchev,N. V. Rajeshkumar,Anirban Maitra,Laura D. Wood,Chenguang Wang,Christopher L. Wolfgang,Ana DeJesus-Acosta,Daniel A. Laheru,Irina M. Shapiro,Mahesh Padval,Jonathan A. Pachter,David T. Weaver,Zeshaan A. Rasheed,William Matsui +20 more
TL;DR: Type I collagen enhances PDAC CSCs, and both kinase-dependent and independent activities of FAK impact PDAC tumor initiation, self-renewal, and metastasis, and the anti-tumor impact ofFAK inhibitors in combination with standard chemotherapy support the clinical testing of this combination.
Meta-analysis of rare adverse events in randomized clinical trials: Bayesian and frequentist methods.
TL;DR: In the rare event setting, treatment effect estimates obtained from traditional meta-analytic methods may be biased and provide poor coverage probability, and this trend worsens when the data have large between-study heterogeneity.
Estimating the Causal Effect of Low Tidal Volume Ventilation on Survival in Patients with Acute Lung Injury.
Weiwei Wang,Daniel O. Scharfstein,Chenguang Wang,Michael J. Daniels,Dale M. Needham,Roy G. Brower +5 more
TL;DR: This work estimates the survival distribution in the counterfactual setting where all patients assigned to LTVV followed the regime by reanalysing data from the original trial and applying the methodology to data from a subsequent trial, which implemented the LTVv regime in both of its study arms and also suffered from non‐adherence.
Cyclin D1 Regulates Cellular Migration through the Inhibition of Thrombospondin 1 and ROCK Signaling
Zhiping Li,Chenguang Wang,Xuanmao Jiao,Yinan Lu,Maofu Fu,Andrew A. Quong,Chip Dye,Jianguo Yang,Maozheng Dai,Xiaoming Ju,Xueping Zhang,Anping Li,Peter D. Burbelo,E. Richard Stanley,Richard G. Pestell +14 more
TL;DR: Mutational analysis of cyclin D1 demonstrated that its effects on cellular adhesion and migration were independent of the pRb and p160 coactivator binding domains and promoted cellular motility through inhibiting ROCK signaling and repressing the metastasis suppressor TSP-1.
Oxidative stress in cancer associated fibroblasts drives tumor-stroma co-evolution: A new paradigm for understanding tumor metabolism, the field effect and genomic instability in cancer cells
Ubaldo E. Martinez-Outschoorn,Renee M. Balliet,Dayana B. Rivadeneira,Barbara Chiavarina,Stephanos Pavlides,Chenguang Wang,Diana Whitaker-Menezes,Kristin M. Daumer,Zhao Lin,Agnieszka K. Witkiewicz,Neal Flomenberg,Anthony Howell,Richard G. Pestell,Erik S. Knudsen,Federica Sotgia,Federica Sotgia,Michael P. Lisanti,Michael P. Lisanti +17 more
TL;DR: Cancer cells use "oxidative stress" in adjacent fibroblasts as an "engine" to fuel their own survival via the stromal production of nutrients, and to drive their own mutagenic evolution towards a more aggressive phenotype, by promoting genomic instability.