Chengcai Wang
Second Military Medical University
5 Papers
27 Citations
Chengcai Wang is an academic researcher from Second Military Medical University. The author has contributed to research in topics: Innate immune system & Proinflammatory cytokine. The author has an hindex of 4, co-authored 5 publications.
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Papers
Immune Responsive Gene 1 (IRG1) Promotes Endotoxin Tolerance by Increasing A20 Expression in Macrophages through Reactive Oxygen Species
Yingke Li,Peng Zhang,Chengcai Wang,Chaofeng Han,Jun Meng,Xingguang Liu,Sheng Xu,Nan Li,Qingqing Wang,Xueyin Shi,Xuetao Cao,Xuetao Cao,Xuetao Cao +12 more
TL;DR: It is demonstrated that inducible IRG1 promotes endotoxin tolerance by increasing A20 expression through ROS, indicating a new molecular mechanism regulating hypoinflammation of sepsis and endotoxinolerance.
165
Flurbiprofen, a Cyclooxygenase Inhibitor, Protects Mice from Hepatic Ischemia/Reperfusion Injury by Inhibiting GSK-3β Signaling and Mitochondrial Permeability Transition
TL;DR: Mechanistic studies revealed that flurbiprofen markedly inhibited glycogen synthase kinase (GSK)-3β activity and increased phosphorylation of GSK-3β at Ser9, which could modulate the adenine nucleotide translocase (ANT)-cyclophilin D (CyP-D) complex and the susceptibility to MPT induction.
The vagus nerve attenuates fulminant hepatitis by activating the Src kinase in Kuppfer cells.
Yingke Li,Zhendong Xu,Yongwei Yu,Hong-bin Yuan,Huji Xu,Qiu-feng Zhu,Chengcai Wang,Xue-yin Shi +7 more
TL;DR: It is demonstrated that the vagus nerve acts as a suppressor in the liver after challenge with LPS plus D‐gal, inhibiting the production of the proinflammatory cytokines TNF and IL‐6.
22
MicroRNA-466l inhibits antiviral innate immune response by targeting interferon-alpha
Yingke Li,Xiaohua Fan,Xing-Ying He,Hai-Jing Sun,Zui Zou,Hongbin Yuan,Hai-Tao Xu,Chengcai Wang,Xue-Yin Shi +8 more
TL;DR: This study has demonstrated that miR-466l could directly target IFN-α expression to inhibit host antiviral innate immune response and can be directly targeted through their 3′ untranslated region (3′UTR).