Polygonatum sibiricum, commonly known as Siberian Solomon's seal, is a traditional herb widely used in various traditional medical systems, especially in East Asia. In ancient China, the use of polygonatum sibiricum in medicine and food was mentioned in Li Shizhen's Bencao Gangmu of traditional Chinese medicine (TCM). It was also used in history of India in Vedic medicine. The plant is rich in bioactive substances such as polysaccharides, saponins, flavonoid and alkaloids.The aim of this review is to understand the pharmacological and pharmacokinetics research progress of the major components of polygonatum sibiricum, and to prospect its potential application and development in the treatment of various diseases.We conducted a systematic literature search against major online databases on the Web, including PubMed, ancient books, patents, PubMed, Wiley, Google Scholar, Web of Science, and others. We select the pharmacological process and mechanism of the main components of polygonatum sibiricum in a variety of diseases, and make a strict but careful supplement and in-depth elaboration to this review.Several studies have demonstrated the strong antioxidant properties of polygonatum extract, which can be attributed to the presence of flavonoids and other polyphenol compounds; for diabetes and other metabolic-related diseases, polygonatum saponins have particular advantages in regulating intestinal flora and lipoprotein concentration in organisms. In addition, the polysaccharides extracted from this plant have a strong anti-inflammatory effect, which is related to its ability to regulate proinflammatory cytokine and mediators. In the aspect of anti-tumor effect, polygonatum derivatives can induce cancer cell apoptosis mainly by adjusting the cell membrane potential and cell cycle. It is worth noting that the combined action of the main components of polygonatum also offers promising solutions for the treatment of the disease.Polygonatum polysaccharide has therapeutic effects on many diseases by adjusting cell signal pathways, polygonatum sibiricum have significant advantages in regulating intestinal flora, inducing apoptosis of tumor cells, activating antioxidant processes, etc. Further research and basic exploration are needed to prove the function and mechanisms of the main components of polygonatum sibiricum on related diseases. The study on the immunomodulatory properties of polygonatum revealed its potentiality of enhancing immune function, which made it an interesting subject for further exploration in the field of immunotherapy. 

Research progress on medicinal components and pharmacological activities of polygonatum sibiricum.

Improving the biocompatibility and antibacterial efficacy of silver nanoparticles functionalized with (LLRR)3 antimicrobial peptide

Wound healing is a crucial biological process for tissue repair and regeneration, preventing infections and complications. There's been a growing interest in exploring sustainable wound healing strategies in recent years. This review examines the use of green-synthesized silver nanoparticles (AgNPs) in sustainable wound healing strategies. It highlights the need for innovative approaches and the challenges posed by infections. The current wound therapies and treatments, highlighting gaps in existing methodologies, are evaluated. This review provides a comprehensive overview of the current state-of-the-art in green synthesis techniques for the synthesis of AgNPs. The properties and characterization of AgNPs are elucidated, providing insights into their efficacy. The biocompatibility of AgNPs in wound healing is also explored, emphasizing safety in medical applications. Green synthesized AgNPs incorporated wound dressings are detailed, showcasing their potential in clinical settings. Challenges and future perspectives are discussed, addressing hurdles to widespread implementation. The conclusion consolidates key findings, offering a synthesized perspective on the potential of green-synthesized AgNPs in revolutionizing current knowledge on innovative approaches for sustainable wound healing practices. 

Advancing Engineered Approaches for Sustainable Wound Regeneration and Repair: Harnessing the Potential of Green Synthesized Silver Nanoparticles

Polygonatum, a versatile plant known for both its medicinal and food uses, exhibits a wide array of beneficial properties with minimal side effects, making it highly promising for the creation of health-oriented products. This review comprehensively examines the active constituents of Polygonatum, delving into their detailed characterization. Additionally, it sheds light on the various bioactive functions of Polygonatum and elucidates the underlying mechanisms governing these functions. Despite the extensive focus on Polygonatum's medicinal aspects in recent studies, its potential applications in the food industry have been largely overlooked. Consequently, this review emphasizes the practical utilization of Polygonatum in food-related contexts. By emphasizing the significance of integrating Polygonatum into the food sector, this review not only presents novel avenues for Polygonatum development but also opens doors for exploring the potentials of other medicinal and edible plant. 

A comprehensive review on the potential applications of medicine Polygonatum species in the food sector

A sodium alginate/silk sericin (SA/SS) film was modified with glycerin (GI) and Polygonatum sibiricum polysaccharide@silver nanoparticles (PSP@AgNPs) to create a SA/SS/GI/PSP@AgNP composite film with antibacterial and antioxidant properties. The physicochemical properties of the SA/SS/GI/PSP@AgNP composite film were analyzed, and its cytocompatibility, antioxidant activity, and antibacterial properties were investigated. The optimum conditions for the preparation of the SA/SS/GI/PSP@AgNP composite film were 2 % SA, 2 % SS, 20 % GI, and 40 μg/mL of PSP@AgNPs. The addition of GI improved the surface smoothness of the composite films, while the presence of PSP@AgNPs did not significantly alter it. Spectroscopic characterization demonstrated that GI and PSP@AgNPs were physically bound to SA/SS. Approximately 53 % of the PSP@AgNP was released from the SA/SS/GI/PSP@AgNP composite film over 24 h of soaking in aqueous solution. The resulting leaching solution did not cause hemolysis or cytotoxicity, indicating its biocompatibility. Additionally, the SA/SS/GI/PSP@AgNP composite film exhibited strong antioxidant and antibacterial properties, and it promoted healing of mouse wounds infected with Staphylococcus aureus.

Enhancing Healing of Infected Wounds with Glycerin‐Modified Sodium Alginate/Silk Sericin Composite Film Functionalized with Polygonatum sibiricum Polysaccharide‐Capped Silver Nanoparticles

Silver Nanoparticles Modified with Polygonatum sibiricum Polysaccharide Improve Biocompatibility and Infected Wound Bacteriostasis

Tunable Aggregation-induced Emission and Emission Colors of Imidazolium and Pyridinium Based Hydrazones.

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Silver Nanoparticles Modified with Polygonatum sibiricum Polysaccharide Improve Biocompatibility and Infected Wound Bacteriostasis

Tunable Aggregation-induced Emission and Emission Colors of Imidazolium and Pyridinium Based Hydrazones.