Cheng Jiang
Hunan University
6 Papers
98 Citations
Cheng Jiang is an academic researcher from Hunan University. The author has contributed to research in topics: Oligonucleotide & DNA ligase. The author has an hindex of 5, co-authored 6 publications.
Chat about Author
Papers
Colorimetric assay for T4 polynucleotide kinase activity based on the horseradish peroxidase-mimicking DNAzyme combined with λ exonuclease cleavage.
TL;DR: A novel colorimetric strategy for estimating the activity of PNK and screening its inhibitors taking advantage of the efficient cleavage of λ exonuclease and the horseradish peroxidase-mimicking DNAzyme (HRPzyme) signal amplification is described.
70
A bioluminescence assay for DNA methyltransferase activity based on methylation-resistant cleavage
TL;DR: A new bioluminescence strategy based on methylation-resistant cleavage and protein expression in vitro to detect DNA MTase activity and could be extended to the detection of other DNA MTases and the corresponding inhibitor screening.
45
Simple, colorimetric detection of microRNA based on target amplification and DNAzyme.
TL;DR: A novel strategy for simple and colorimetric detection of miRNA by combining target amplification with DNAzyme is developed and multicopies of target analogues were generated that function in the same manner as the target, accompanied by the accumulation of signal elements.
15
A simple and highly sensitive DNAzyme-based assay for nicotinamide adenine dinucleotide by ligase-mediated inhibition of strand displacement amplification.
TL;DR: A novel DNAzyme-based visual assay strategy for NAD(+) based on ligase-mediated inhibition of the strand displacement amplification (SDA) that provides a simple colorimetric approach with high selectivity against most interferences and a detection limit as low as 50 pM.
13
Simultaneous identification of point mutations via DNA ligase-mediated gold nanoparticle assembly.
TL;DR: A novel approach for a genotyping assay that could achieve simultaneous identification of multiple point mutations via a ligase-mediated gold nanoparticle assembly is reported and it is demonstrated that the wild and the mutant types could be simultaneously determined successfully.