Cheng Cao
Harvard University
10 Papers
132 Citations
Cheng Cao is an academic researcher from Harvard University. The author has contributed to research in topics: Phosphorylation & Tyrosine kinase. The author has an hindex of 8, co-authored 8 publications.
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Papers
Catalase is regulated by ubiquitination and proteosomal degradation. Role of the c-Abl and Arg tyrosine kinases.
TL;DR: It is demonstrated that mouse cells deficient in both c-Abl and Arg exhibit increased catalase stability and thatCatalase is subject to ubiquitination and degradation by the 26S proteosome, and in concert with these results, human 293 cells expressing catalases mutated at Y231 and Y386 exhibit attenuated levels of reactive oxygen species when exposed to hydrogen peroxide.
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The ARG tyrosine kinase interacts with Siva-1 in the apoptotic response to oxidative stress.
TL;DR: It is demonstrated that ARG associates with the proapoptotic Siva-1 protein, and the apoptotic response to oxidative stress is attenuated in ARG-deficient cells and that this defect is corrected by reconstituting ARG expression.
70
Functional interaction between the c-Abl and Arg protein-tyrosine kinases in the oxidative stress response.
TL;DR: The present studies demonstrate that reactive oxygen species (ROS) induce the formation of c-Abl and Arg heterodimers and that both c- Abl andArg are necessary as effectors in the apoptotic response to oxidative stress.
42
Ubiquitination and degradation of the Arg tyrosine kinase is regulated by oxidative stress.
TL;DR: The results show that Arg is stabilized in response to 0.1 mM H2O2 by autophosphorylation of Y-261, consistent with involvement of the Arg kinase function in regulating Arg levels, and that Arg stability is conferred by phosphorylated Y- 261.
29
Single-stranded RNA viruses activate and hijack host apical DNA damage response kinases for efficient viral replication
Pengcheng Li,Chenchen Xu,Xiaoyan Zhang,Cheng Cao,Xuejuan Wang,Gang Cai +5 more
- 01 Apr 2022
TL;DR: In this paper , the authors reveal that single-stranded RNA virus replication specifically elicits host ATM- and ATR-mediated pathway activation and boosts their expression, and that activated ATM and ATr are hijacked to the virus replication factory in the cytoplasm and facilitate viral gene expression and replication.