Chenchen Pan

TL;DR: In this paper, a pressure-driven, nanobody-based whole-body immunolabeling technology was developed to enhance the signal of fluorescent proteins by up to two orders of magnitude, which allowed them to image and quantify subcellular details through bones, skin and highly autofluorescent tissues of intact transparent mice.

TL;DR: In this paper, a series of cell- and region-specific loss-and gain-of-function models were used to show that hyperleptinemia promotes obesity-induced hypertension via a HIF1α-VEGF signaling cascade in hypothalamic astrocytes while establishing a novel mechanistic link that connects hypothalamic micro-angioarchitecture with control over systemic blood pressure.

TL;DR: A deep learning solution called AIMOS that automatically segments major organs and the skeleton in less than a second, orders of magnitude faster than prior algorithms and addresses the issue of human bias by identifying the regions where humans are most likely to disagree.

TL;DR: The high versatility of vDISCO applied to boost the fluorescence signal of genetically expressed reporters and clear multiple dissected organs and tissues, as well as how to image processed samples using multiple fluorescence microscopy systems are shown.