Chen-Yu Wang
Harvard University
10 Papers
5 Citations
Chen-Yu Wang is an academic researcher from Harvard University. The author has contributed to research in topics: XIST & X-inactivation. The author has an hindex of 6, co-authored 10 publications. Previous affiliations of Chen-Yu Wang include Howard Hughes Medical Institute.
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Papers
SMCHD1 Merges Chromosome Compartments and Assists Formation of Super-Structures on the Inactive X.
TL;DR: A stepwise model for Xi folding is presented, where SMCHD1 attenuates a hidden layer of Xi architecture to facilitate Xist spreading and erosion of heterochromatic silencing.
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Xist Deletional Analysis Reveals an Interdependency between Xist RNA and Polycomb Complexes for Spreading along the Inactive X.
David Colognori,David Colognori,Hongjae Sunwoo,Hongjae Sunwoo,Andrea J. Kriz,Andrea J. Kriz,Chen-Yu Wang,Chen-Yu Wang,Jeannie T. Lee,Jeannie T. Lee +9 more
TL;DR: Repeat B is a multifunctional element that integrates interdependent Xist/Polycomb spreading, silencing, and changes in chromosome architecture and suggests a positive feedback mechanism between RNA initiator and protein effectors.
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A mixed modality approach towards Xi reactivation for Rett syndrome and other X-linked disorders
Lieselot L. G. Carrette,Chen-Yu Wang,Chunyao Wei,William H. Press,Weiyuan Ma,Raymond J. Kelleher,Jeannie T. Lee +6 more
TL;DR: A mixed modality approach that combines a small-molecule inhibitor of DNA methylation and an antisense oligonucleotide against Xist RNA achieves up to 30,000-fold methyl-CpG binding protein 2 upregulation in cultured cells, providing proof of concept for a mixedmodality approach for treating X-linked disorders in females.
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PRC1 collaborates with SMCHD1 to fold the X-chromosome and spread Xist RNA between chromosome compartments.
TL;DR: It is concluded that Xist, PRC1, and SMCHD1 collaborate in an obligatory, sequential manner to partition, fuse, and direct self-association of Xi compartments required for proper spreading of Xist RNA.
Xist RNA antagonizes the SWI/SNF chromatin remodeler BRG1 on the inactive X chromosome.
Teddy Jégu,Roy Blum,Roy Blum,Jesse C. Cochrane,Lin Yang,Lin Yang,Chen-Yu Wang,Chen-Yu Wang,Maud-Emmanuelle Gilles,David Colognori,David Colognori,Attila Szanto,Attila Szanto,Sharon K. Marr,Robert E. Kingston,Jeannie T. Lee,Jeannie T. Lee +16 more
TL;DR: The noncoding RNA Xist regulates the accessibility of select chromatin regions on the inactive X chromosome (Xi) by directly inhibiting the chromosome remodeler BRG1 and by expelling it from the Xi.
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