4 Papers
Chen Yang is an academic researcher from East China University of Science and Technology. The author has contributed to research in topics: Epigenetics & Chromatin. The author has an hindex of 1, co-authored 3 publications. Previous affiliations of Chen Yang include ShanghaiTech University.
Chat about Author
Papers
Simultaneous Epigenetic Perturbation and Genome Imaging Reveal Distinct Roles of H3K9me3 in Chromatin Architecture and Transcription
Ying Feng,Ying Feng,Yao Wang,Xiangnan Wang,Xiaohui He,Chen Yang,Chen Yang,Ardalan Naseri,Thoru Pederson,Jing Zheng,Shaojie Zhang,Xiao Xiao,Wei Xie,Hanhui Ma +13 more
TL;DR: The role of H3K9me3 in genome organization could be partially separated from its function in gene repression, as revealed by the results of EpiGo-KRAB, which is sufficient to induce de novo heterochromatin-like domain formation.
The local density of H3K9me3 dictates the stability of HP1α condensates-mediated genomic interactions.
TL;DR: In this paper , the role of histone H3 lysine 9 (H3K9me3) in the formation of constitutive heterochromatin nanodomains is investigated.
CRISPR-based Live Imaging of Epigenetic Modification-Mediated Genome Reorganization
Yaoyu Feng,Yaoyu Feng,Wang Y,Chen Yang,Chen Yang,Ardalan Naseri,Thoru Pederson,Jing Zheng,Xiao Xiao,Shaojie Zhang,Wei Xie,Hanhui Ma +11 more
TL;DR: A CRISPR-based EpiGo (Epigenetic perturbation induced Genome organization) system to track epigenetic modification-mediated relocation, interaction or reorganization of genomic regions in living cells is developed.
Simultaneous epigenetic perturbation and genome imaging reveal distinct roles of H3K9me3 in chromatin architecture and transcription
Ying Feng,Yao Wang,Xiangnan Wang,Xiaohui He,Chen Yang,Ardalan Naseri,Thoru Pederson,Jing Zheng,Shaojie Zhang,Xiao Xiao,Wei Xie,Hanhui Ma +11 more
TL;DR: The role of H3K9me3 in genome organization could be partially separated from its function in gene repression, as revealed by results of EpiGo-KRAB-induced heterochromatin-like domain formation.