Chen-Yan Yan
Shanghai Jiao Tong University
10 Papers
Chen-Yan Yan is an academic researcher from Shanghai Jiao Tong University. The author has contributed to research in topics: Medicine & Thyroid. The author has an hindex of 2, co-authored 4 publications.
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Papers
Mutation screening of the TSHR gene in 220 Chinese patients with congenital hypothyroidism.
Ya Fang,Feng Sun,Rui-Jia Zhang,Chang-Run Zhang,Chen-Yan Yan,Zheng Zhou,Qian-Yue Zhang,Lu Li,Ying-Xia Ying,Shuang-Xia Zhao,Jun Liang,Huai-Dong Song,Huai-Dong Song +12 more
TL;DR: One novel TSHR variant was found and four genetic alterations revealed important role of the Ile216, Ala275, Asn372, Ser567 residues in signaling.
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The TPO mutation screening and genotype-phenotype analysis in 230 Chinese patients with congenital hypothyroidism
Rui-Jia Zhang,Feng Sun,Feng Chen,Ya Fang,Chen-Yan Yan,Chang-Run Zhang,Ying-Xia Ying,Zheng Wang,Cao-Xu Zhang,Feng-Yao Wu,Bing Han,Jun Liang,Shuang-Xia Zhao,Huai-Dong Song +13 more
TL;DR: The findings indicated that the residual enzymatic activity of TPO was correlated with clinical phenotypes of CH patients with TPO biallelic mutations.
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NUCB2 polymorphisms are associated with an increased risk for type 2 diabetes in the Chinese population.
TL;DR: NUCB2 polymorphisms could have a pivotal role in the presence of type 2 diabetes mellitus and sex-specific SNPs of N UCB2 could account for the differences in clinical features of T2DM between male and female subpopulations.
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Pathogenic variations in MAML2 and MAMLD1 contribute to congenital hypothyroidism due to dyshormonogenesis by regulating the Notch signalling pathway
Feng-Yao Wu,Ruimeng Yang,Hai Yang Zhang,Ming Zhan,Ping Tu,Cao-Xu Zhang,Mei Dong,Ren-Jie Cui,Xiao Yu Liu,Liu Yang,Chen-Yan Yan,Feng Sun,Zheng Wang,Jun Liang,Huai-Dong Song,Feng Cheng +15 more
TL;DR: In this article , the authors identified three mastermind-like family gene variants in CH and revealed that both canonical and non-canonical Notch signalling affected thyroid hormone biosynthesis, and these three variants blocked the expression of genes associated with thyroid thyroid biosynthesis.
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Large-scale forward genetic screening of zebrafish affecting thyroid development.
Jia-Ping Wan,Zheng Wang,Cao-Xu Zhang,Liu Yang,Chen-Yan Yan,Feng-Yao Wu,Huai-Dong Song,Mei Dong +7 more
TL;DR: In this article , a forward mutagenesis screen for identifying genes involved in the development and function of the thyroid follicular cells was carried out in the zebrafish model to identify genes and signaling pathways that regulate the thyroid development.
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