13 Papers
5 Citations
Chen Yan is an academic researcher from Second Military Medical University. The author has contributed to research in topics: Medicine & Oxidative stress. The author has an hindex of 1, co-authored 5 publications.
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Papers
The deubiquitinase USP11 ameliorates intervertebral disc degeneration by regulating oxidative stress-induced ferroptosis via deubiquitinating and stabilizing Sirt3
TL;DR: In this article , USP11 was identified to stabilize Sirt3 via directly binding to Sirt 3 and deubiquitinating it, thus relieving intervertebral disc degeneration by increasing oxidative stress-induced ferroptosis.
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Hesperidin mitigates oxidative stress-induced ferroptosis in nucleus pulposus cells via Nrf2/NF-κB axis to protect intervertebral disc from degeneration
TL;DR: In this article , the effect of Hesperidin on intervertebral disc degeneration (IVDD) has been investigated in mice and human nucleus pulposus (HNP) cells.
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Catalytic Nanodots-Driven Pyroptosis Suppression in Nucleus Pulposus for Antioxidant Intervention of Intervertebral Disc Degeneration.
Kaiqiang Sun,Chen Yan,Xinyue Dai,Yangyang Shi,Fudong Li,Liang Chen,Jingchuan Sun,Yu Chen,Jiangang Shi +8 more
TL;DR: Carbonized Mn-containing nanodots are developed as ROS-scavenging catalytic biomaterials to suppress pyroptosis of nucleus pulposus cells to efficiently alleviate IVDD and mechanistically unveils an efficient strategy for the treatment of IVDD.
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The clinical value of three-dimensional measurement in the diagnosis of thoracic myelopathy caused by ossification of the ligamentum flavum.
Chen Yan,Hao-Yuan Tan,Chenglong Ji,Xue-Wei Yu,Huai-Cheng Jia,Fudong Li,Gui-Cheng Jiang,Wei-Shi Li,Fei-Fei Zhou,Zhen Ye,Jingchuan Sun,Jiangang Shi +11 more
TL;DR: The results demonstrate the superiority of the OLFV ratio over the conventional 1D and 2D computed tomography (CT)-based radiological parameters for the diagnosis of OLF-induced thoracic myelopathy.
How much space of the spinal canal should be restored by hoisting the vertebrae-OPLL complex for sufficient decompression in anterior controllable antedisplacement and fusion? A multicenter clinical radiological study
Chen Yan,Huai-Cheng Jia,Hao-Yuan Tan,Xue-Wei Yu,Ming Li,Xiao-Yi Zhou,Ming-Yuan Yang,Dian-Wen Song,Qing-Hua Zhao,Guo-Zheng Li,Sheng-Hui Tang,Bin-Sheng Yu,Lintao Li,Jingchuan Sun,Jiangang Shi +14 more
TL;DR: It is suggested that it is essential for neurologic recovery to restore the spinal canal to more than 80.7% of its original size (postoperative APD ratio >80.7%), and restoration to less than itsOriginal size ( postoperative APd ratio <100%) will help reduce the incidence of surgical complications.
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