The invention discloses a compound with a chemical structure as described in the specification, and pharmaceutically acceptable salts, salt crystalline hydrates and salt crystalline solvents thereof. In the chemical structure, R1 is H or OH; R2 is H or OH; and R3 is an alkyl group with 1 to 4 carbon atoms. Antiviral activity and primary hepatocyte uptaking experiment results show that the compound has better antiviral activity and liver cell transfer specificity than adefovir dipivoxil, and can be used for preparation of drugs treating hepatitis B virus infection.

Adefovir thio L-amino acid ester and mono bile acid ester derivatives and preparation method thereof

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Adefovir thio L-amino acid ester and mono bile acid ester derivatives and preparation method thereof