Chen Xu
Fudan University
17 Papers
58 Citations
Chen Xu is an academic researcher from Fudan University. The author has contributed to research in topics: GiST & HER2/neu. The author has an hindex of 7, co-authored 17 publications.
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Papers
Trastuzumab anti-tumor efficacy in patient-derived esophageal squamous cell carcinoma xenograft (PDECX) mouse models.
Xian-hua Wu,Jingchuan Zhang,Ruheng Zhen,Jing Lv,Li Zheng,Xinying Su,Guanshan Zhu,Paul R. Gavine,Song-Tao Xu,Shaohua Lu,Jun Hou,Yalan Liu,Chen Xu,Yunshan Tan,Liang Xie,Xiaolu Yin,Deming He,Qunsheng Ji,Yingyong Hou,Di Ge +19 more
TL;DR: This study demonstrates Trastuzumab-induced tumor regressions in HER-2 positive tumors, and highlights PIK3CA mutation as a potential resistance mechanism to Trastzumab treatment in pre-clinical patient-derived EC xenograft models.
•Journal Article
Molecular mechanism of icariin on rat asthmatic model.
TL;DR: Icariin could regulate the imbalance of Th1/Th2 cytokines in asthmatic rat pulmonary tissue and spleen lymphocytes and could inhibit the activation of NF‐&kgr;B p65 protein in astHmatic rat lung tissue.
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Clinical significance of assessing Her2/neu expression in gastric cancer with dual tumor tissue paraffin blocks.
Xiaowen Ge,Haixing Wang,Haiying Zeng,Xuejuan Jin,Akesu Sujie,Chen Xu,Yalan Liu,Jie Huang,Yuan Ji,Yunshan Tan,Tian-shu Liu,Yingyong Hou,Jing Qin,Yihong Sun,Xinyu Qin +14 more
TL;DR: The results implied that using dual paraffin blocks to assess Her2/neu expression of GC may help identify more patients with Her2 /neu-positive GC who could benefit from targeted therapy, by reducing false-negative rate of Her2 status assessment.
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Subsequent intra-abdominal fibromatosis mimicking recurrent gastrointestinal stromal tumor
Dongxian Jiang,Deming He,Yingyong Hou,Weiqi Lu,Yuan Shi,Qin Hu,Shaohua Lu,Chen Xu,Yalan Liu,Ju Liu,Yunshan Tan,Xiong-zeng Zhu +11 more
TL;DR: Although intra-abdominal fibromatosis subsequent to GIST is very rare, it is of clinical significance in imatinib era as an influencing factor for making clinical decision.
•Journal Article
Clinical and pathological studies of borderline gastrointestinal stromal tumors.
Yuan Shi,Yingyong Hou,Shaohua Lu,Yang Zhou,Jian-Fang Xu,Yuan Ji,Jun Hou,Chen Xu,Yalan Liu,Yunshan Tan,Xiong-zeng Zhu +10 more
TL;DR: The proposed borderline GIST criteria in the current study may complement the existing NIH criteria, based primarily on tumor size and mitotic count, in the evaluation of the biological behaviors of GISTs.
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