Chen Wang
3 Papers
Chen Wang is an academic researcher. The author has contributed to research in topics: G protein-coupled receptor & Receptor. The author has co-authored 2 publications.
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Papers
Mechanism of agonist-induced activation of the human itch receptor MRGPRX1
Bing Siang Gan,Leiye Yu,Haifeng Yang,Haizhan Jiao,Bin Pang,Yian Chen,Chen Wang,Rui Lv,Zhijian Cao,Ruobing Ren +9 more
TL;DR: In this paper , the structure of Gq-coupled MRGPRX1 in complex with a synthetic agonist compound 16 in an active conformation at an overall resolution of 3.0 Å via a NanoBiT tethering strategy was reported.
Strong protective effect of the APOL1 p.N264K variant against G2-associated FSGS and kidney disease
Yask Gupta,David S. Friedman,Michelle McNulty,Atlas Khan,Brandon M. Lane,Chen Wang,Juntao Ke,Gina Y. Jin,Benjamin Wooden,Andrea L Knob,Tze Yin Lim,Gerald B. Appel,Kinsie Huggins,Lili Liu,Adele Mitrotti,Megan Chryst Stangl,Andrew S. Bomback,Rik Westland,Monica Bodria,Maddalena Marasa,Ning Shang,David J. Cohen,R. John Crew,William Morello,Pietro A. Canetta,Jai Radhakrishnan,Jeremiah Martino,Qingxue Liu,Wendy K. Chung,Angelica Espinoza,Yunhao Liu,Wei Wei,QiPing Feng,Chunhua Weng,Yilu Fang,Iftikhar J. Kullo,Mohammadreza Naderian,Nita A. Limdi,Marguerite R. Irvin,Hemant K. Tiwari,Sumit Mohan,Maya K. Rao,Geoffrey K. Dube,Ninad S. Chaudhary,Orlando M. Gutiérrez,Suzanne E. Judd,Mary Cushman,Leslie A. Lange,Ethan M. Lange,Daniel L. Bivona,Miguel Verbitsky,Cheryl Winkler,Jeffrey B. Kopp,Dominick Santoriello,Ibrahim Batal,S. Veloso,Brant Pinheiro,Eduardo A. Oliveira,Ana Cristina Simões e Silva,Isabella Pisani,Enrico Fiaccadori,Fangming Lin,Loreto Gesualdo,Antonio Amoroso,Gian Marco Ghiggeri,Vivette D. D'Agati,Riccardo Magistroni,Eimear E. Kenny,R. Loos,Giovanni Montini,Friedhelm Hildebrandt,Dirk S. Paul,Slavé Petrovski,David Goldstein,Matthias Kretzler,Rasheed Gbadegesin,Ali G. Gharavi,Krzysztof Kiryluk,Matthew G. Sampson,Martin R. Pollak,Simone Sanna-Cherchi +80 more
TL;DR: It is shown that the presence of the AP OL1 p.N264K missense variant, when co-inherited with the G2 APOL1 risk allele, substantially reduces the penetrance of the G1G2 and G2G2 high-risk genotypes by rendering these genotypes low-risk.
2
The structural basis of itch receptor MRGPRX1 activation
Bing Siang Gan,Leiye Yu,Haifeng Yang,Haizhan Jiao,Bin Pang,Yian Chen,Chen Wang,Rui Lv,Hongli Hu,Zhijian Cao,Ruobing Ren +10 more
TL;DR: In this paper , the structure of Gq-coupled MRGPRX1 in complex with a synthetic agonist compound 16 in an active conformation at an overall resolution of 3.0 angstrom via a NanoBiT tethering strategy was reported.