Chen Wang
Chinese Academy of Sciences
24 Papers
173 Citations
Chen Wang is an academic researcher from Chinese Academy of Sciences. The author has contributed to research in topics: Signal transduction & Biology. The author has an hindex of 18, co-authored 24 publications.
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Papers
The E3 Ubiquitin Ligase AMFR and INSIG1 Bridge the Activation of TBK1 Kinase by Modifying the Adaptor STING
TL;DR: An essential role of the ER proteins AMFR and INSIG1 in innate immunity is uncovers, revealing an important missing link in the STING signaling pathway.
329
Stress Induces Dynamic, Cytotoxicity-Antagonizing TDP-43 Nuclear Bodies via Paraspeckle LncRNA NEAT1-Mediated Liquid-Liquid Phase Separation
Chen Wang,Yongjia Duan,Gang Duan,Qiangqiang Wang,Kai Zhang,Xue Deng,Beituo Qian,Jinge Gu,Zhiwei Ma,Shuang Zhang,Lin Guo,Cong Liu,Yanshan Fang +12 more
TL;DR: An unexpected role is reported in the formation of dynamic, reversible, liquid droplet-like nuclear bodies (NBs) in response to stress, which suggests a stress-mitigating role and mechanism of TDP-43 NBs, whose dysfunction may be involved in ALS pathogenesis.
172
Herc5 Attenuates Influenza A Virus by Catalyzing ISGylation of Viral NS1 Protein
Yujie Tang,Gongxun Zhong,Lianhui Zhu,Xing Liu,Yufei Shan,Huapeng Feng,Zhigao Bu,Hualan Chen,Chen Wang +8 more
TL;DR: It is reported that Herc5 could catalyze conjugation of ISG15 onto IAV-NS1 protein, the critical virulence factor of IAV, and uncovers the direct antiviral function and mechanism of this novel modification.
151
Conservation of the STING-Mediated Cytosolic DNA Sensing Pathway in Zebrafish
TL;DR: The zebrafish larva is established as a useful model for studying HSV-1 infection and represents an amenable model for the investigation of cytosolic DNA sensing mechanisms, shedding light on the conservation of the STING antiviral signaling pathway.
77
Herpes virus proteins ICP0 and BICP0 can activate NF-κB by catalyzing IκBα ubiquitination
Lirong Diao,Bianhong Zhang,Junkai Fan,Xiang Gao,Shaogang Sun,Kai Yang,Dan Xin,Naihe Jin,Yunqi Geng,Chen Wang +9 more
TL;DR: It is reported that ICP0 and BICP0 could induce NF-κB translocation from cytoplasm into nucleus and strongly activate NF-σB responsive genes specifically, and this process was dependent on the RING domain of both proteins.
72