8 Papers
51 Citations
Chen Ning is an academic researcher from University of Texas Health Science Center at Houston. The author has contributed to research in topics: Adenosine & Signal transduction. The author has an hindex of 6, co-authored 8 publications. Previous affiliations of Chen Ning include Central South University & University of Texas at Austin.
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Papers
Interleukin-6 Underlies Angiotensin II-induced Hypertension and Chronic Renal Damage
Weiru Zhang,Wei Wang,Hong Yu,Yujin Zhang,Yingbo Dai,Chen Ning,Lijian Tao,Hong Sun,Hong Sun,Rodney E. Kellems,Michael R. Blackburn,Yang Xia +11 more
TL;DR: Both the mouse and human studies reported here provide evidence that angiotensin II induces IL-6 production in the kidney, and that, in addition to its role in hypertension, increased IL- 6 may play an important pathogenic role in CKD by inducing fibrotic gene expression and ET-1 gene expression.
212
Elevated sphingosine-1-phosphate promotes sickling and sickle cell disease progression
Yujin Zhang,Vladimir Berka,Anren Song,Kaiqi Sun,Wei Wang,Wei Wang,Weiru Zhang,Weiru Zhang,Chen Ning,Chen Ning,Chonghua Li,Qibo Zhang,Mikhail Bogdanov,Danny C. Alexander,Michael V. Milburn,Mostafa H. Ahmed,Han Lin,Modupe Idowu,Jun Zhang,Gregory J. Kato,Osheiza Abdulmalik,Wenzheng Zhang,William Dowhan,Rodney E. Kellems,Pumin Zhang,Jianping Jin,Martin K. Safo,Ah-Lim Tsai,Harinder S. Juneja,Yang Xia,Yang Xia +30 more
TL;DR: In murine models of SCD, it is demonstrated that elevated erythrocyte sphingosine kinase 1 (SPHK1) underlies sickling and disease progression by increasing S1P levels in the blood, revealing that a SPHK1-mediated elevation of S 1P contributes to Sickling and promotes disease progression.
Elevated Ecto-5'-nucleotidase-Mediated Increased Renal Adenosine Signaling Via A2B Adenosine Receptor Contributes to Chronic Hypertension
Weiru Zhang,Yujin Zhang,Wei Wang,Yingbo Dai,Chen Ning,Renna Luo,Kaiqi Sun,Louise E. Glover,Almut Grenz,Hong Sun,Lijian Tao,Wenzheng Zhang,Sean P. Colgan,Michael R. Blackburn,Holger K. Eltzschig,Rodney E. Kellems,Yang Xia +16 more
TL;DR: In this paper, the expression level of 5′-ectonucleotidase (CD73) was significantly increased in the kidneys of angiotensin II-infused mice, an animal model of hypertensive nephropathy.
83
Excess adenosine A2B receptor signaling contributes to priapism through HIF-1α mediated reduction of PDE5 gene expression
Chen Ning,Jiaming Wen,Yujin Zhang,Yingbo Dai,Wei Wang,Weiru Zhang,Lin Qi,Almut Grenz,Holger K. Eltzschig,Michael R. Blackburn,Rodney E. Kellems,Yang Xia +11 more
TL;DR: It is revealed that excess adenosine‐mediated ADORA2B signaling underlies reduced penile PDE activity by decreasing PDE5 gene expression in a HIF‐1α‐dependent manner and provide new insight for the pathogenesis of priapism and novel therapies for the disease.
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Excessive penile norepinephrine level underlies impaired erectile function in adenosine A1 receptor deficient mice.
Chen Ning,Chen Ning,Lin Qi,Jiaming Wen,Jiaming Wen,Yujin Zhang,Weiru Zhang,Weiru Zhang,Wei Wang,Wei Wang,Michael R. Blackburn,Rodney E. Kellems,Yang Xia +12 more
TL;DR: The results show that ADORA1 is enriched on neuron cells where it functions to control NE release and reduced cavernosal smooth muscle contraction, therefore facilitating penile erection.
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