Chen Ma
Peking Union Medical College
26 Papers
85 Citations
Chen Ma is an academic researcher from Peking Union Medical College. The author has contributed to research in topics: Chemistry & Mycobacterium tuberculosis. The author has an hindex of 7, co-authored 22 publications.
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Papers
Identification of novel benzothiopyranone compounds against Mycobacterium tuberculosis through scaffold morphing from benzothiazinones.
Peng Li,Bin Wang,Xinwei Zhang,Sarah M. Batt,Gurdyal S. Besra,Tingting Zhang,Chen Ma,Dongfeng Zhang,Ziyun Lin,Gang Li,Haihong Huang,Yu Lu +11 more
TL;DR: New insight is provided into the structural and pharmacological requirements for DprE1 inhibitors as potent antitubercular agents as well as the potential clinical candidate for treatment of tuberculosis.
34
Discovery of a Conformationally Constrained Oxazolidinone with Improved Safety and Efficacy Profiles for the Treatment of Multidrug-Resistant Tuberculosis.
Hongyi Zhao,Bin Wang,Lei Fu,Gang Li,Haijia Lu,Yuke Liu,Li Sheng,Yan Li,Baoxi Zhang,Yang Lu,Chen Ma,Haihong Huang,Dongfeng Zhang,Yu Lu +13 more
TL;DR: A conformationally constrained oxazolidinone 19c is discovered with improved antituberculosis activity and safety profile through a focused lead optimization effort and displayed superior in vivo efficacy in a mouse TB infection model.
33
Systematic evaluation of structure-activity relationships of the riminophenazine class and discovery of a C2 pyridylamino series for the treatment of multidrug-resistant tuberculosis.
Binna Liu,Kai Liu,Yu Lu,Dongfeng Zhang,Tianming Yang,Xuan Li,Chen Ma,Meiqin Zheng,Bin Wang,Gang Zhang,Fei Wang,Zhenkun Ma,Chun Li,Haihong Huang,Dali Yin +14 more
TL;DR: The study reveals that the central tricyclic phenazine system and the pendant aromatic rings are important for anti-tuberculosis activity, but the phenyl groups attached to the C2 and N5 position of clofazimine can be replaced by a pyridyl group to provide analogs with improved physicochemical properties and pharmacokinetic characteristics.
The optimization of xanthine derivatives leading to HBK001 hydrochloride as a potent dual ligand targeting DPP-IV and GPR119.
Gang Li,Bingxu Meng,Baokun Yuan,Yi Huan,Tian Zhou,Qian Jiang,Lei Lei,Li Sheng,Weiping Wang,Ningbo Gong,Yang Lu,Chen Ma,Yan Li,Zhufang Shen,Haihong Huang +14 more
TL;DR: A series of xanthine compounds derived from the previous hit 20i with modification on the terminal side chain was discovered through ring formation strategy and will be useful for the future drug design for more potent and safer dual ligand targeting DPP-IV and GPR119 for the treatment of diabetes.
22
Simultaneous Determination of 15 Sulfonate Ester Impurities in Phentolamine Mesylate, Amlodipine Besylate, and Tosufloxacin Tosylate by LC-APCI-MS/MS.
TL;DR: An LC-MS/MS method was developed and validated for the simultaneous determination of 15 sulfonate esters, including methyl, ethyl, propyl, isopropyl, and n-butyl esters of methanesulfonate, benzenesulf onate, and p-toluenesulfonates in drug products.