15 Papers
14 Citations
Chen Liu is an academic researcher from Huazhong University of Science and Technology. The author has contributed to research in topics: Medicine & Ovarian cancer. The author has an hindex of 4, co-authored 10 publications.
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Papers
Cancer history is an independent risk factor for mortality in hospitalized COVID-19 patients: a propensity score-matched analysis.
Yifan Meng,Wanrong Lu,Ensong Guo,Jia Liu,Bin Yang,Ping Wu,Shitong Lin,Ting Peng,Yu Fu,Fuxia Li,Zizhuo Wang,Yuan Li,Rourou Xiao,Chen Liu,Yuhan Huang,Funian Lu,Xue Wu,Lixin You,Ding Ma,Chaoyang Sun,Peng Wu,Gang Chen +21 more
TL;DR: Cancer history was the only independent risk factor for COVID-19 among common comorbidities, while other comor morbidities may act through other factors, and several laboratory parameters were significantly different between cancer patients and matched noncancer patients.
Dynamics and Correlation Among Viral Positivity, Seroconversion, and Disease Severity in COVID-19: A Retrospective Study
Yu Fu,Yongsheng Li,Ensong Guo,Liang He,Jia Liu,Bin Yang,Fuxia Li,Zizhuo Wang,Yuan Li,Rourou Xiao,Chen Liu,Yuhan Huang,Xue Wu,Funian Lu,Lixin You,Tianyu Qin,Chaolong Wang,Kezhen Li,Peng Wu,Ding Ma,Chaoyang Sun,Gang Chen +21 more
TL;DR: Wang et al. as discussed by the authors described patterns of viral polymerase chain reaction (PCR) positivity and evaluated their correlations with seroconversion and disease severity in COVID-19 patients.
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Drug screening model meets cancer organoid technology
TL;DR: This review presents the recent developments of tumor organoid for drug screening, which will introduce from four aspects, including the stability/credibility, types, application, deficiency and prospect of the tumor organoids model for drug screened.
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WEE1 inhibition induces anti-tumor immunity by activating ERV and the dsRNA pathway.
Ensong Guo,Rourou Xiao,Yifan Wu,Funian Lu,Chen Liu,Bin Yang,Xi Li,Yu Fu,Zizhuo Wang,Yuan Li,Yuhan Huang,Fuxia Li,Xue Wu,Lixin You,Tianyu Qin,Yiling Lu,Xiaoyuan Huang,Ding Ma,Gordon B. Mills,Chaoyang Sun,Gang Chen +20 more
TL;DR: The authors showed that targeting WEE1 up-regulates immune signaling through the double-stranded RNA (dsRNA) viral defense pathway with subsequent responsiveness to immune checkpoint blockade even in cGAS/STING-deficient tumors, which is a typical phenotype across multiple cancer types.
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Inhibiting the IRE1α Axis of the Unfolded Protein Response Enhances the Antitumor Effect of AZD1775 in TP53 Mutant Ovarian Cancer
Rourou Xiao,Lixin You,Li Zhang,Ensong Guo,Faming Zhao,Bin Yang,Xi Li,Funian Lu,Zizhuo Wang,Chen Liu,Wen-Ju Peng,Wenting Li,Xiaohang Yang,Yingyu Dou,Jing-Bing Liu,Wei Wang,Tianyu Qin,Xiao-Xiao Zhang,Fuxia Li,Yang Jin,Qingping Zeng,Beibei Wang,Gordon B. Mills,Gang Chen,Xia Sheng,Chaoyang Sun +25 more
TL;DR: The data reveal an important dual role of the UPR signaling network in mtTP53 ovarian cancer models in response to AZD 1775 and suggest that inhibition of the IRE1α‐XBP1s pathway may enhance the efficacy of AZD1775 in the clinics.
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