High moisture permeability, excellent mechanical properties in a wet state, high water-holding capability, and high exudate absorption make bacterial nanocellulose (BNC) a favorable candidate for biomedical device production, especially wound dressings. The lack of antibacterial activity and healing-promoting ability are the main drawbacks that limit its wide application. Pullulan (Pul) is a nontoxic polymer that can promote wound healing. Zinc oxide nanoparticles (ZnO-NPs) are well-known as a safe antibacterial agent. In this study, aminoalkylsilane was chemically grafted on a BNC membrane (A-g-BNC) and used as a bridge to combine BNC with Pul-ZnO-NPs hybrid electrospun nanofibers. FTIR results confirmed the successful production of A-g-BNC/Pul-ZnO. The obtained dressing demonstrated blood clotting performance better than that of BNC. The dressing showed an ability to release ZnO, and its antibacterial activity was up to 5 log values higher than that of BNC. The cytotoxicity of the dressing toward L929 fibroblast cells clearly showed safety due to the proliferation of fibroblast cells. The animal test in a rat model indicated faster healing and re-epithelialization, small blood vessel formation, and collagen synthesis in the wounds covered by A-g-BNC/Pul-ZnO. The new functional dressing, fabricated with a cost-effective and easy method, not only showed excellent antibacterial activity but could also accelerate wound healing.

Functionalization of Aminoalkylsilane-Grafted Bacterial Nanocellulose with ZnO-NPs-Doped Pullulan Electrospun Nanofibers for Multifunctional Wound Dressing.

The invention relates to a porous elastic polyvinyl alcohol/bacterial nano-cellulose composite hydrogel tube, as well as a preparation method and application of the composite hydrogel tube. The composite hydrogel tube comprises a surface layer and a lining layer, wherein the surface layer has a smooth surface, and the lining layer is of a nano-fiber network structure. The preparation method comprises the following steps: pretreating the bacterial nano-cellulose composite hydrogel tube; preparing a polyvinyl alcohol solution; freezing at minus 80 DEG C for molding; unfreezing by ethanol at minus 20 DEG C; and soaking in ultrapure water at room temperature to replace the ethanol. The porous elastic polyvinyl alcohol/bacterial nano-cellulose composite hydrogel tube is controllable in mechanical performance and can meet the requirements of multiple tissue repairing stents, the nano-fiber network structure of the composite hydrogel tube is advantageous to cell adhesion and proliferation, and the mutually communicated porous structure of the composite hydrogel structure is advantageous to nutrition transmission and cell ingrowth; and the porous elastic polyvinyl alcohol/bacterial nano-cellulose composite hydrogel tube is simple in preparation process and low in cost, and has a good application prospect in vascular repairing stents and nerve repairing stents.

Porous elastic polyvinyl alcohol/bacterial nano-cellulose composite hydrogel tube, as well as preparation method and application of composite hydrogel tube

The invention relates to a method for preparing a nanocellulose/polyvinyl alcohol hydrogel membrane with high ionic conductivity. The method includes the following steps of 1, preparing nanocelluloseand dispersing the nanocellulose in an aqueous solution to obtain a nanocellulose solution; 2, adding polyvinyl alcohol into the nanocellulose solution obtained in step 1 and uniformly dispersing polyvinyl alcohol to obtain a nanocellulose/polyvinyl alcohol mixture; 3, adding isopropanol into the nanocellulose/polyethylene mixture obtained in step 2, uniformly stirring the mixture above, pouring the mixture into a culture dish for freezing-thawing cycle, and then obtaining the nanocellulose/polyvinyl alcohol hydrogel membrane with high ionic conductivity. According to the nanocellulose/polyvinyl alcohol hydrogel membrane, the free volume among gel molecular chains is large, there are many pore structures, and the ionic conductivity is high.

Method for preparing nanocellulose/polyvinyl alcohol hydrogel membrane with high ionic conductivity

The invention relates to a preparation method of a bacterial cellulose composite by pressure control, which includes steps of acquiring a bacterial nano-cellulose BNC with a three-dimensional networkstructure through culturing; purifying to obtain the purified BNC; performing moisture evaporation and drying to obtain dry BNC; acting the pressure containing an exogenous molecule on dry BNC; makingBNC expand by controlling pressure, and making the exogenous molecule enter the BNC network hole; after absorbing or fixing, carrying out post-treatment to obtain BNC composite. The preparation method is acted on BNC by the fluid pressure specific to the characteristic of low rehydration rate of the of bacterial nano-cellulose, thus the bacterial nano-cellulose can be quickly recovered to a highwater-holding state; meanwhile, the exogenous molecule is introduced, the composite can be prepared; the process is simple and quick; the method has important significance in the biological material domain.

Preparation method of bacterial cellulose composite by pressure control

The invention relates to the field of medical biological composites, in particular to a eucalyptus nanocrystalline cellulose-reinforced hydroxyapatite/polyvinyl alcohol composite. With eucalyptus cellulose serving as a reinforcing material, the composite is prepared by polymer blending of the eucalyptus cellulose and hydroxyapatite/polyvinyl in a solution blending freezing-thawing cyclic treatmentmode. The prepared composite has the potential of being used for artificial articular cartilage in the biomedical field.

Eucalyptus nanocrystalline cellulose-reinforced medical biological composite and preparation method thereof

The invention relates to a preparation method of an antimicrobial bacterial cellulose material The method comprises the following steps: adding an organosilicon quaternary ammonium salt into a solvent to obtain an organosilicon quaternary ammonium salt solution; and adding the organosilicon quaternary ammonium salt solution into a bacterial cellulose hydrogel, regulating the pH value to 20-70, carrying out stirring or oscillating reaction at 5-95 DEG C for 24-72 hours, and cleaning The method is simple to operate and mild in conditions; and the grafting reaction occurs on the fiber surface, so that the grafting ratio is high The graft-modified bacterial cellulose material has the advantages of bacterial resistance, protein adsorptivity, cell adhesion promotion characteristic, and specific pH responsivity and temperature responsivity The antimicrobial bacterial cellulose material has excellent resistance to Staphylococcus aureus and other bacteria, is beneficial to adhesion and growth of the cells in the material, and enhances the application potential of the bacterial cellulose material in the fields of antimicrobial wound dressings, intelligent responsive drug-slow-release carriers, tissue engineering stent biomedicine and the like

Preparation method of antimicrobial bacterial cellulose material

The utility model relates to a porous elastic polyvinyl alcohol/bacteria nano-crystalline cellulose composite hydrogel pipe The porous elastic polyvinyl alcohol/bacteria nano-crystalline cellulose composite hydrogel pipe comprises a surface layer and an inner layer, wherein the surface of the surface layer is in a smooth state, and the inner layer is of a nano-fiber network structure The porous elastic polyvinyl alcohol/bacteria nano-crystalline cellulose composite hydrogel pipe has the advantages of being controllable in mechanics property of machinery and capable of meeting the requirements of multiple tissue repairing supports, the nano-fiber network structure of the composite hydrogel pipe contributes to the adhesion and the multiplication of cells, the intercommunicated porous structure of the porous elastic polyvinyl alcohol/bacteria nano-crystalline cellulose composite hydrogel pipe contributes to the transmission of nutrient substances and the ingrowth of the cells, and the porous elastic polyvinyl alcohol/bacteria nano-crystalline cellulose composite hydrogel pipe has a good application prospect in vascular repairing supports and nerve repairing supports

Porous elastic polyvinyl alcohol/bacteria nano-crystalline cellulose composite hydrogel pipe

The utility model relates to a mold for a composite hydrogel pipe. The mold comprises a polypropylene pipe and a glass pipe, the glass pipe is sleeved with the polypropylene pipe, a cavity is formed between the glass pipe and the polypropylene pipe, and the two ends of the polypropylene pipe and the two ends of the glass pipe are fixedly sealed with rubber plugs. The mold can be used for manufacturing the composite hydrogel pipe and has good application prospects in vascular repair stents and neural repair stents.

Mold for composite hydrogel pipe

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Preparation method of antimicrobial bacterial cellulose material

Porous elastic polyvinyl alcohol/bacterial nano-cellulose composite hydrogel tube, as well as preparation method and application of composite hydrogel tube

Porous elastic polyvinyl alcohol/bacteria nano-crystalline cellulose composite hydrogel pipe

Mold for composite hydrogel pipe